5HJS

Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ESRF BEAMLINE ID14-1
Synchrotron site	ESRF
Beamline	ID14-1
Temperature [K]	100
Detector technology	CCD
Collection date	2005-11-17
Detector	ADSC QUANTUM 4
Wavelength(s)	0.9330
Spacegroup name	P 4 21 2
Unit cell lengths	125.007, 125.007, 92.339
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	32.460 - 1.720
R-factor	0.2099
Rwork	0.208
R-free	0.23840
RMSD bond length	0.010
RMSD bond angle	1.010
Data reduction software	HKL-2000
Data scaling software	HKL-2000
Phasing software	REFMAC
Refinement software	BUSTER-TNT (BUSTER 2.11.5)

Data quality characteristics

	Overall
Low resolution limit [Å]	63.850
High resolution limit [Å]	1.720
Number of reflections	61151
<I/σ(I)>	7.4
Completeness [%]	78.6
Redundancy	7.1

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, HANGING DROP		293	12% PEG MME 2000, 0.1M Ammonium Sulfate, 0.1M Tris buffer pH 7.8