5HJS

Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Oxysterols receptor LXR-alpha	polymer	283	32866.4	2	UniProt (Q13133) Pfam (PF00104) In PDB	Homo sapiens (Human)	Liver X receptor alpha,Nuclear receptor subfamily 1 group H member 3
2	C, D	Nuclear receptor coactivator 1	polymer	25	2806.2	2	UniProt (Q15788) Pfam (PF08832) In PDB	Homo sapiens	NCoA-1,Class E basic helix-loop-helix protein 74,bHLHe74,Protein Hin-2,RIP160,Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1,SRC-1
3	A, B	2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide	non-polymer		518.0	2	Chemie (668)
4	C, D	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5		water	water		18.0	328	Chemie (HOH)

Sequence modifications

A, B: 18 - 283 (UniProt: Q13133)

PDB	External Database	Details
Met 1	-	expression tag
Lys 2	-	expression tag
His 3	-	expression tag
Gln 4	-	expression tag
His 5	-	expression tag
Gln 6	-	expression tag
His 7	-	expression tag
Gln 8	-	expression tag
His 9	-	expression tag
Gln 10	-	expression tag
His 11	-	expression tag
Gln 12	-	expression tag
His 13	-	expression tag
Gln 14	-	expression tag
Gln 15	-	expression tag
Pro 16	-	expression tag
Leu 17	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	71345.1
Non-Polymers*	Number of molecules	4
	Total formula weight	1228.1
All*	Total formula weight	72573.3

*Water molecules are not included.