8JZM
The inhibitor of Toll-like receptor signaling o-vanillin binds covalently to MAL/TIRAP Lys-210
Summary for 8JZM
| Entry DOI | 10.2210/pdb8jzm/pdb |
| Descriptor | Toll/interleukin-1 receptor domain-containing adapter protein (1 entity in total) |
| Functional Keywords | toll-like receptor (tlr) signalling the cytoplasmic tir (toll/interleukin-1 receptor) domains, immune system |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 16031.20 |
| Authors | Rahaman, M.H.,Jia, X.,Maxwell, M.J.,Mobli, M.,Kobe, B. (deposition date: 2023-07-05, release date: 2024-05-01) |
| Primary citation | Rahaman, M.H.,Thygesen, S.J.,Maxwell, M.J.,Kim, H.,Mudai, P.,Nanson, J.D.,Jia, X.,Vajjhala, P.R.,Hedger, A.,Vetter, I.,Haselhorst, T.,Robertson, A.A.B.,Dymock, B.,Ve, T.,Mobli, M.,Stacey, K.J.,Kobe, B. o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. J Enzyme Inhib Med Chem, 39:2313055-2313055, 2024 Cited by PubMed: 38416868DOI: 10.1080/14756366.2024.2313055 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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