7JQD

Crystal Structure of PAC1r in complex with peptide antagonist

Summary for 7JQD

• Entry DOI: 10.2210/pdb7jqd/pdb
• Descriptor: Pituitary adenylate cyclase-activating polypeptide type I receptor, Peptide-43 (3 entities in total)
• Functional Keywords: ecd, complex, antagonist, gpcr, signaling protein-antagonist complex, signaling protein/antagonist
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 16248.37

Authors

Piper, D.E.,Hu, E.,Fang-Tsao, H. (deposition date: 2020-08-10, release date: 2021-03-24, Last modification date: 2023-10-18)

• Primary citation: Hu, E.,Hong, F.T.,Aral, J.,Long, J.,Piper, D.E.,Poppe, L.,Andrews, K.L.,Hager, T.,Davis, C.,Li, H.,Wong, P.,Gavva, N.,Shi, L.,Zhu, D.X.D.,Lehto, S.G.,Xu, C.,Miranda, L.P.; Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model.; J.Med.Chem., 64:3427-3438, 2021; PubMed: 33715378; DOI: 10.1021/acs.jmedchem.0c01396

Experimental method