PDB: 263 件ウェブページステータス検索Chemie searchBIRD

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5D6X	Crystal structure of double tudor domain of human lysine demethylase KDM4A 分子名称: Lysine-specific demethylase 4A, SULFATE ION 著者 Wang, F, Su, Z, Denu, J.M, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) 登録日 2015-08-13 公開日 2015-11-25 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.153 Å) 主引用文献 Reader domain specificity and lysine demethylase-4 family function. Nat Commun, 7, 2016
7BCY	X-ray structure of WDR5delta24 bound to the Kaposi's sarcoma herpesvirus LANA win motif peptide 分子名称: ORF 73, WD repeat-containing protein 5 著者 McVey, C.E, Kaye, K.M. 登録日 2020-12-21 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res., 49, 2021
7BED	X-ray structure of WDR5 bound to the WDR5 win motif peptide 分子名称: SULFATE ION, WD repeat-containing protein 5 著者 McVey, C.E, Kaye, K.M. 登録日 2020-12-23 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res., 49, 2021
7EA1	Crystal Structure of Spindlin1 bound to SPINDOC Docpep2 分子名称: Peptide from Spindlin interactor and repressor of chromatin-binding protein, Spindlin-1 著者 Zhao, F, Li, H. 登録日 2021-03-05 公開日 2022-06-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional inhibition to be published
7E9M	Crystal Structure of Spindlin1 bound to SPINDOC Docpep3 分子名称: Peptide from Spindlin interactor and repressor of chromatin-binding protein, Spindlin-1 著者 Zhao, F, Li, H. 登録日 2021-03-04 公開日 2022-06-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional inhibition to be published
3O70	PHD-type zinc finger of human PHD finger protein 13 分子名称: GLYCEROL, PHD finger protein 13, ZINC ION 著者 Lam, R, Bian, C.B, Xu, C, Kania, J, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) 登録日 2010-07-29 公開日 2010-09-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3. Elife, 5, 2016
3MP6	Complex Structure of Sgf29 and dimethylated H3K4 分子名称: H3K4me2 peptide, Maltose-binding periplasmic protein,LINKER,SAGA-associated factor 29, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose 著者 Li, J, Wu, M, Ruan, J, Zang, J. 登録日 2010-04-25 公開日 2011-05-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation Embo J., 30, 2011
3MWY	Crystal structure of the chromodomain-ATPase portion of the yeast Chd1 chromatin remodeler 分子名称: Chromo domain-containing protein 1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER 著者 Hauk, G, Bowman, G.D. 登録日 2010-05-06 公開日 2010-09-29 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 The chromodomains of the Chd1 chromatin remodeler regulate DNA access to the ATPase motor. Mol.Cell, 39, 2010
4FWE	Native structure of LSD2 /AOF1/KDM1b in spacegroup of C2221 at 2.13A 分子名称: CITRATE ANION, FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1B, ... 著者 Zhang, Q, Chen, Z. 登録日 2012-07-01 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b Cell Res., 23, 2013
2XAG	Crystal structure of LSD1-CoREST in complex with para-bromo-(-)-trans- 2-phenylcyclopropyl-1-amine 分子名称: 3-(4-BROMOPHENYL)PROPANAMIDE, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... 著者 Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. 登録日 2010-03-31 公開日 2010-05-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
4FWF	Complex structure of LSD2/AOF1/KDM1b with H3K4 mimic 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3.1, Lysine-specific histone demethylase 1B, ... 著者 Zhang, Q, Chen, Z. 登録日 2012-07-01 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b Cell Res., 23, 2013
4GUR	Crystal structure of LSD2-NPAC with H3 in space group P21 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Histone H3.3, ... 著者 Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. 登録日 2012-08-29 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.506 Å) 主引用文献 LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
8F2Z	LSD1-CoREST in complex with AW2, short soaking 分子名称: Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,13R)-3-([1,1'-biphenyl]-4-yl)-1-hydroxy-10,11-dimethyl-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name) 著者 Caroli, J, Mattevi, A. 登録日 2022-11-09 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 to be published
8F30	LSD1-CoREST in complex with AW2, long soaking 分子名称: Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-5-{5-[3-([1,1'-biphenyl]-4-yl)propanoyl]-7,8-dimethyl-2,4-dioxo-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl}-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name) 著者 Caroli, J, Mattevi, A. 登録日 2022-11-09 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 to be published
8F59	LSD1-CoREST in complex with AW2 and SNAG peptide 分子名称: Lysine-specific histone demethylase 1A, REST corepressor 1, Zinc finger protein SNAI1, ... 著者 Caroli, J, Mattevi, A. 登録日 2022-11-12 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 to be published
8F6S	LSD1-CoREST in complex with T105 分子名称: 3-[(1R,2S)-2-(cyclobutylamino)cyclopropyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide, Lysine-specific histone demethylase 1A, REST corepressor 1, ... 著者 Caroli, J, Mattevi, A. 登録日 2022-11-17 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 to be published
8F8Y	PHF2 (PHD+JMJ) in Complex with VRK1 N-Terminal Peptide 分子名称: 1,2-ETHANEDIOL, Lysine-specific demethylase PHF2, SULFATE ION, ... 著者 Horton, J.R, Cheng, X. 登録日 2022-11-22 公開日 2023-01-18 最終更新日 2023-02-08 実験手法 X-RAY DIFFRACTION (3.06 Å) 主引用文献 A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2. J.Biol.Chem., 299, 2022
8F8Z	PHF2 (PHD+JMJ) in Complex with H3 Histone N-Terminal Peptide 分子名称: 1,2-ETHANEDIOL, H3 N-Terminal Peptide, Lysine-specific demethylase PHF2, ... 著者 Horton, J.R, Cheng, X. 登録日 2022-11-22 公開日 2023-01-18 最終更新日 2023-02-08 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2. J.Biol.Chem., 299, 2022
4HSU	Crystal structure of LSD2-NPAC with H3(1-26)in space group P21 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3, Lysine-specific histone demethylase 1B, ... 著者 Chen, F, Dong, Z, Fang, J, Xu, Y. 登録日 2012-10-30 公開日 2013-02-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.988 Å) 主引用文献 Structural insight into substrate recognition by histone demethylase LSD2/KDM1b. Cell Res., 23, 2013
2XAH	Crystal structure of LSD1-CoREST in complex with (+)-trans-2- phenylcyclopropyl-1-amine 分子名称: 3-PHENYLPROPANAL, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... 著者 Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. 登録日 2010-03-31 公開日 2010-05-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
2XAS	Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2580, 14e) 分子名称: 3-[4-({N-[(BENZYLOXY)CARBONYL]-L-PHENYLALANYL}AMINO)PHENYL]PROPANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... 著者 Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. 登録日 2010-03-31 公開日 2010-05-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
2XAJ	Crystal structure of LSD1-CoREST in complex with (-)-trans-2- phenylcyclopropyl-1-amine 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, PHENYLETHYLENECARBOXYLIC ACID, ... 著者 Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. 登録日 2010-03-31 公開日 2010-05-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
4GUS	Crystal structure of LSD2-NPAC with H3 in space group P3221 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Histone H3.3, ... 著者 Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. 登録日 2012-08-29 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
4GU0	Crystal structure of LSD2 with H3 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3.3, Lysine-specific histone demethylase 1B, ... 著者 Chen, F, Yang, H, Dong, Z, Fang, J, Zhu, T, Gong, W, Xu, Y. 登録日 2012-08-29 公開日 2013-02-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.103 Å) 主引用文献 Structural insight into substrate recognition by histone demethylase LSD2/KDM1b Cell Res., 23, 2013
8FDV	LSD1-CoREST in complex N-formyl FAD and SNAG peptide 分子名称: Lysine-specific histone demethylase 1A, REST corepressor 1, Zinc finger protein SNAI1, ... 著者 Caroli, J, Mattevi, A. 登録日 2022-12-05 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 to be published

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