8G4Z
 
 | | E. coli DHFR complex with NADP+ and folate: EF-X off model by Laue diffraction (no electric field) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Klureza, M.A, Hekstra, D.R. | | 登録日 | 2023-02-10 | | 公開日 | 2024-01-03 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
6ZWC
 | | Z-SBTub2 photoswitch bound to tubulin-DARPin D1 complex | | 分子名称: | 2-[2-(3,4,5-trimethoxyphenyl)ethyl]-1,3-benzothiazole, Designed Ankyrin Repeat Protein (DARPIN) D1, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Wranik, M, Weinert, T, Olieric, N, Gao, L, Kraus, Y.C.M, Bingham, R, Ntouliou, E, Ahlfeld, J, Thorn-Seshold, O, Steinmetz, M.O, Standfuss, J. | | 登録日 | 2020-07-28 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | A Robust, GFP-Orthogonal Photoswitchable Inhibitor Scaffold Extends Optical Control over the Microtubule Cytoskeleton.
Cell Chem Biol, 28, 2021
|
|
5MMP
 | | E. coli DNA Gyrase B 24 kDa ATPase domain in complex with 1-ethyl-3-[5-pyridin-4-yl-8-(pyridin-3-ylamino)-isoquinolin-3-yl]-urea | | 分子名称: | 1-ethyl-3-[5-pyridin-4-yl-8-(pyridin-3-ylamino)isoquinolin-3-yl]urea, DNA gyrase subunit B | | 著者 | Panchaud, P, Bruyere, T, Blumstein, A.-C, Bur, D, Chambovey, A, Ertel, E.A, Gude, M, Hubschwerlen, C, Jacob, L, Kimmerlin, T, Pfeifer, T, Prade, L, Seiler, P, Ritz, D, Rueedi, G. | | 登録日 | 2016-12-12 | | 公開日 | 2017-04-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.
J. Med. Chem., 60, 2017
|
|
8IUM
 | | Cryo-EM structure of the tafluprost acid-bound human PTGFR-Gq complex | | 分子名称: | (~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E})-3,3-bis(fluoranyl)-4-phenoxy-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, G subunit alpha (q), ... | | 著者 | Wu, C, Xu, Y, Xu, H.E. | | 登録日 | 2023-03-24 | | 公開日 | 2023-07-12 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | | 主引用文献 | Ligand-induced activation and G protein coupling of prostaglandin F 2 alpha receptor.
Nat Commun, 14, 2023
|
|
8IUK
 | | Cryo-EM structure of the PGF2-alpha-bound human PTGFR-Gq complex | | 分子名称: | (Z)-7-[(1R,2R,3R,5S)-3,5-bis(oxidanyl)-2-[(E,3S)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, G subunit alpha (q), ... | | 著者 | Wu, C, Xu, Y, Xu, H.E. | | 登録日 | 2023-03-24 | | 公開日 | 2023-07-12 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (2.67 Å) | | 主引用文献 | Ligand-induced activation and G protein coupling of prostaglandin F 2 alpha receptor.
Nat Commun, 14, 2023
|
|
8F6M
 | | Complex of Rabbit muscle pyruvate kinase with ADP and the phosphonate analogue of PEP mimicking the Michaelis complex. | | 分子名称: | (E)-2-METHYL-3-PHOSPHONOACRYLATE, ADENOSINE-5'-DIPHOSPHATE, ALANINE, ... | | 著者 | Holyoak, T, Fenton, A.W. | | 登録日 | 2022-11-16 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | PYK-SubstitutionOME: an integrated database containing allosteric coupling, ligand affinity and mutational, structural, pathological, bioinformatic and computational information about pyruvate kinase isozymes.
Database (Oxford), 2023, 2023
|
|
6EHS
 | | E. coli Hydrogenase-2 chemically reduced structure | | 分子名称: | CARBONMONOXIDE-(DICYANO) IRON, DITHIONITE, FE3-S4 CLUSTER, ... | | 著者 | Carr, S.B, Evans, R.M, Beaton, S.E, Armstrong, F.A. | | 登録日 | 2017-09-15 | | 公開日 | 2018-04-18 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The structure of hydrogenase-2 fromEscherichia coli: implications for H2-driven proton pumping.
Biochem. J., 475, 2018
|
|
5FGZ
 | | E. coli PBP1b in complex with FPI-1465 | | 分子名称: | MOENOMYCIN, Penicillin-binding protein 1B, [[(3~{R},6~{S})-1-methanoyl-6-[[(3~{S})-pyrrolidin-3-yl]oxycarbamoyl]piperidin-3-yl]amino] hydrogen sulfate | | 著者 | King, D.T, Strynadka, N.C.J. | | 登録日 | 2015-12-21 | | 公開日 | 2016-01-20 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-beta-Lactamases and Penicillin-Binding Proteins.
Acs Chem.Biol., 11, 2016
|
|
6EN9
 | | E. coli Hydrogenase-2 (hydrogen reduced form) | | 分子名称: | CARBONMONOXIDE-(DICYANO) IRON, FE3-S4 CLUSTER, Hydrogenase-2 large chain, ... | | 著者 | Carr, S.B, Beaton, S.E, Evans, R.M, Armstrong, F.A. | | 登録日 | 2017-10-04 | | 公開日 | 2018-04-18 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The structure of hydrogenase-2 fromEscherichia coli: implications for H2-driven proton pumping.
Biochem. J., 475, 2018
|
|
7Z15
 | | E. coli C-P lyase bound to a PhnK/PhnL dual ABC dimer and ADP + Pi | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, ... | | 著者 | Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E. | | 登録日 | 2022-02-24 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (1.93 Å) | | 主引用文献 | Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
|
|
8UXB
 | |
4XKU
 | | E coli BFR variant Y114F | | 分子名称: | Bacterioferritin, SULFATE ION | | 著者 | Hemmings, A.M, Le Brun, N.E, Bradley, J.M. | | 登録日 | 2015-01-12 | | 公開日 | 2015-12-16 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Three Aromatic Residues are Required for Electron Transfer during Iron Mineralization in Bacterioferritin.
Angew.Chem.Int.Ed.Engl., 54, 2015
|
|
6S1S
 | | Crystal structure of AmpC from Pseudomonas aeruginosa in complex with [3-(2-carboxyvinyl)phenyl]boronic acid] inhibitor | | 分子名称: | (~{E})-3-[3-(dihydroxyboranyl)phenyl]prop-2-enoic acid, Beta-lactamase, PHOSPHATE ION | | 著者 | Kekez, I, Vicario, M, Bellio, P, Tosoni, E, Celenza, G, Blazquez, J, Tondi, D, Cendron, L. | | 登録日 | 2019-06-19 | | 公開日 | 2019-10-09 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Phenylboronic Acids Probing Molecular Recognition against Class A and Class C beta-lactamases.
Antibiotics, 8, 2019
|
|
2Y2T
 | |
4XKS
 | | E. coli BFR variant Y45F | | 分子名称: | Bacterioferritin, SULFATE ION | | 著者 | Hemmings, A.M, Le Brun, N.E, Bradley, J.M. | | 登録日 | 2015-01-12 | | 公開日 | 2015-12-16 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Three Aromatic Residues are Required for Electron Transfer during Iron Mineralization in Bacterioferritin.
Angew.Chem.Int.Ed.Engl., 54, 2015
|
|
7T20
 | | E. coli DnaB bound to ssDNA and AMPPNP | | 分子名称: | DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Oakley, A.J, Xu, Z.Q. | | 登録日 | 2021-12-02 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Sequence of conformation changes of DnaB helicase during DNA unwinding and priming in Escherichia coli
To Be Published
|
|
7T21
 | | E. coli DnaB bound to ssDNA and ADP-AlF4 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, ... | | 著者 | Oakley, A.J, Xu, Z.Q. | | 登録日 | 2021-12-02 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | | 主引用文献 | Sequence of conformation changes of DnaB helicase during DNA unwinding and priming in Escherichia coli
To Be Published
|
|
7T22
 | |
4YLP
 | |
7TOS
 | | E. coli 70S ribosomes bound with the ALS/FTD-associated dipeptide repeat protein PR20 | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | | 登録日 | 2022-01-24 | | 公開日 | 2022-05-25 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Nat Commun, 13, 2022
|
|
4YLO
 | |
4YLN
 | |
8SXX
 | | E. coli dodecamer SIR2 | | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SIR2-like domain-containing protein | | 著者 | Shen, Z.F, Lin, Q.P, Fu, T.M. | | 登録日 | 2023-05-24 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense.
Mol.Cell, 83, 2023
|
|
2XSK
 | | E. coli curli protein CsgC - SeCys | | 分子名称: | ACETATE ION, CSGC | | 著者 | Salgado, P.S, Taylor, J.D, Cota, E, Matthews, S.J. | | 登録日 | 2010-09-29 | | 公開日 | 2010-12-29 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Extending the Usability of the Phasing Power of Diselenide Bonds: Secys Sad Phasing of Csgc Using a Non-Auxotrophic Strain.
Acta Crystallogr.,Sect.D, 67, 2011
|
|
9GBV
 | |
