8F6M

Complex of Rabbit muscle pyruvate kinase with ADP and the phosphonate analogue of PEP mimicking the Michaelis complex.

Summary for 8F6M

Entry DOI	10.2210/pdb8f6m/pdb
Related	8F5T 8F5U
Descriptor	Pyruvate kinase PKM, ADENOSINE-5'-DIPHOSPHATE, SUCCINIC ACID, ... (9 entities in total)
Functional Keywords	glycolysis, metabolic kinase, central metabolism, cytosolic protein
Biological source	Oryctolagus cuniculus (rabbit)
Total number of polymer chains	8
Total formula weight	473373.51
Authors	Holyoak, T.,Fenton, A.W. (deposition date: 2022-11-16, release date: 2023-05-24, Last modification date: 2023-10-25)
Primary citation	Swint-Kruse, L.,Dougherty, L.L.,Page, B.,Wu, T.,O'Neil, P.T.,Prasannan, C.B.,Timmons, C.,Tang, Q.,Parente, D.J.,Sreenivasan, S.,Holyoak, T.,Fenton, A.W. PYK-SubstitutionOME: an integrated database containing allosteric coupling, ligand affinity and mutational, structural, pathological, bioinformatic and computational information about pyruvate kinase isozymes. Database (Oxford), 2023:-, 2023 Cited by PubMed: 37171062 DOI: 10.1093/database/baad030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation