8F6M
Complex of Rabbit muscle pyruvate kinase with ADP and the phosphonate analogue of PEP mimicking the Michaelis complex.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Pyruvate kinase PKM | polymer | 531 | 58114.0 | 8 | UniProt (P11974) Pfam (PF00224) Pfam (PF02887) | Oryctolagus cuniculus (rabbit) | Pyruvate kinase muscle isozyme,Threonine-protein kinase PKM2,Tyrosine-protein kinase PKM2 |
| 2 | DA, HB, I, PA, T (C, F, A, D, B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 5 | Chemie (ADP) | |||
| 3 | BB, DC, EA, IA, J... (E, H, C, A, F...) | SUCCINIC ACID | non-polymer | 118.1 | 12 | Chemie (SIN) | |||
| 4 | BC, FA, GA, HC, JB... (H, C, F, A, D...) | MANGANESE (II) ION | non-polymer | 54.9 | 15 | Chemie (MN) | |||
| 5 | AB, CC, HA, LB, M... (E, H, C, F, A...) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
| 6 | CB, EC, JA, NB, O... (E, H, C, F, A...) | ALANINE | non-polymer | 89.1 | 8 | Chemie (ALA) | |||
| 7 | AA, BA, CA, DB, EB... (B, E, H, C, F...) | GLYCEROL | non-polymer | 92.1 | 26 | Chemie (GOL) | |||
| 8 | AC, IB, TB, XA (H, F, G, E) | (E)-2-METHYL-3-PHOSPHONOACRYLATE | non-polymer | 166.1 | 4 | Chemie (GZ3) | |||
| 9 | IC, JC, KC, LC, MC... (A, B, C, D, E...) | water | water | 18.0 | 2882 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 0 - 530 (UniProt: P11974)
| PDB | External Database | Details |
|---|---|---|
| Ala 400 | Ser 401 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 464912.1 | |
| Non-Polymers* | Number of molecules | 78 |
| Total formula weight | 8461.4 | |
| All* | Total formula weight | 473373.5 |
