5FGZ

E. coli PBP1b in complex with FPI-1465

Summary for 5FGZ

Entry DOI	10.2210/pdb5fgz/pdb
Descriptor	Penicillin-binding protein 1B, MOENOMYCIN, [[(3~{R},6~{S})-1-methanoyl-6-[[(3~{S})-pyrrolidin-3-yl]oxycarbamoyl]piperidin-3-yl]amino] hydrogen sulfate, ... (4 entities in total)
Functional Keywords	penicillin-binding-protein, inhibitor, complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Escherichia coli (strain K12)
Total number of polymer chains	1
Total formula weight	85213.28
Authors	King, D.T.,Strynadka, N.C.J. (deposition date: 2015-12-21, release date: 2016-01-20, Last modification date: 2019-11-20)
Primary citation	King, A.M.,King, D.T.,French, S.,Brouillette, E.,Asli, A.,Alexander, J.A.,Vuckovic, M.,Maiti, S.N.,Parr, T.R.,Brown, E.D.,Malouin, F.,Strynadka, N.C.,Wright, G.D. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-beta-Lactamases and Penicillin-Binding Proteins. Acs Chem.Biol., 11:864-868, 2016 Cited by PubMed: 26731698 DOI: 10.1021/acschembio.5b00944 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation