6ZWC

Z-SBTub2 photoswitch bound to tubulin-DARPin D1 complex

Summary for 6ZWC

Entry DOI	10.2210/pdb6zwc/pdb
Related	6ZWB
Descriptor	Tubulin alpha-1B chain, Tubulin beta-2B chain, Designed Ankyrin Repeat Protein (DARPIN) D1, ... (8 entities in total)
Functional Keywords	photopharmacology, microtubule dynamics, cytoskeleton, tubulin polymerisation inhibitor, colchicine, antimitotic, azobenzene, cell division, cell cycle, spatiotemporal control
Biological source	synthetic construct More
Total number of polymer chains	3
Total formula weight	119592.87
Authors	Wranik, M.,Weinert, T.,Olieric, N.,Gao, L.,Kraus, Y.C.M.,Bingham, R.,Ntouliou, E.,Ahlfeld, J.,Thorn-Seshold, O.,Steinmetz, M.O.,Standfuss, J. (deposition date: 2020-07-28, release date: 2020-12-23, Last modification date: 2024-01-31)
Primary citation	Gao, L.,Meiring, J.C.M.,Kraus, Y.,Wranik, M.,Weinert, T.,Pritzl, S.D.,Bingham, R.,Ntouliou, E.,Jansen, K.I.,Olieric, N.,Standfuss, J.,Kapitein, L.C.,Lohmuller, T.,Ahlfeld, J.,Akhmanova, A.,Steinmetz, M.O.,Thorn-Seshold, O. A Robust, GFP-Orthogonal Photoswitchable Inhibitor Scaffold Extends Optical Control over the Microtubule Cytoskeleton. Cell Chem Biol, 28:228-, 2021 Cited by PubMed: 33275880 DOI: 10.1016/j.chembiol.2020.11.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.04 Å)

Structure validation