PDB: 12119 件ウェブページステータス検索Chemie searchBIRD

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7RTC	Crystal structure of the ARM domain from Drosophila SARM1 in complex with NaMN 分子名称: NAD(+) hydrolase sarm1, NICOTINATE MONONUCLEOTIDE 著者 Gu, W, Ve, T, Kobe, B. 登録日 2021-08-13 公開日 2021-09-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.31 Å) 主引用文献 Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Exp Neurol, 345, 2021
4OQT	LINGO-1/Li81 Fab complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of Li81 Fab, ... 著者 Pepinsky, R.B, Arndt, J.W, Quan, C, Gao, Y, Quintero-Monzon, O, Lee, X, Mi, S. 登録日 2014-02-10 公開日 2014-05-14 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.23 Å) 主引用文献 Structure of the LINGO-1-Anti-LINGO-1 Li81 Antibody Complex Provides Insights into the Biology of LINGO-1 and the Mechanism of Action of the Antibody Therapy. J.Pharmacol.Exp.Ther., 350, 2014
6D4E	Crystal Structure of a Fc Fragment of Rhesus macaque (Macaca mulatta) IgG1. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Fc Fragment of IgG1 著者 Gohain, N, Tolbert, W.D, Pazgier, M. 登録日 2018-04-18 公開日 2019-05-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses. Mabs, 11, 2019
7D7L	The crystal structure of SARS-CoV-2 papain-like protease in complex with YM155 分子名称: 1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione, CAFFEINE, GLYCEROL, ... 著者 Zhao, Y, Sun, L, Yang, H.T, Rao, Z.H. 登録日 2020-10-04 公開日 2021-04-21 最終更新日 2021-11-17 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors. Protein Cell, 12, 2021
7D7K	The crystal structure of SARS-CoV-2 papain-like protease in apo form 分子名称: 1,2-ETHANEDIOL, CAFFEINE, Non-structural protein 3, ... 著者 Zhao, Y, Sun, L, Yang, H.T, Rao, Z.H. 登録日 2020-10-04 公開日 2021-04-21 最終更新日 2021-11-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors. Protein Cell, 12, 2021
6D4N	Crystal structure of a Fc fragment of Rhesus macaque (Macaca mulatta) IgG4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Fc fragment of IgG4 著者 Gohain, N, Tolbert, W.D, Pazgier, M. 登録日 2018-04-18 公開日 2019-05-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses. Mabs, 11, 2019
6WXN	EGFR(T790M/V948R) in complex with LN3844 分子名称: CHLORIDE ION, Epidermal growth factor receptor, MAGNESIUM ION, ... 著者 Heppner, D.E, Eck, M.J. 登録日 2020-05-11 公開日 2021-05-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites. J.Med.Chem., 65, 2022
6D4I	Crystal Structure of a Fc Fragment of Rhesus macaque (Macaca mulatta) IgG2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Fc fragment of IgG2 著者 Gohain, N, Tolbert, W.D, Pazgier, M. 登録日 2018-04-18 公開日 2019-05-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses. Mabs, 11, 2019
7T5F	Botulinum neurotoxin Type B Light Chain complexed with nanobodies JLJ-G3 and JNE-B10 分子名称: Botulinum neurotoxin type B, IODIDE ION, JLJ-G3, ... 著者 Jin, R, Lam, K.-H. 登録日 2021-12-12 公開日 2021-12-29 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies. Plos Pathog., 18, 2022
7TQR	Crystal Structure of histidine ammonia lyase from Thermoplasma acidophilum 分子名称: Probable histidine ammonia-lyase 著者 Wu, K, Dulchavsky, M, Bardwell, J.C.A. 登録日 2022-01-26 公開日 2022-04-06 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Microreactor equipped with naturally acid-resistant histidine ammonia lyase from an extremophile. Mater Adv, 3, 2022
8WC7	Cryo-EM structure of the ZH8667-bound mTAAR1-Gs complex 分子名称: 2-[4-(3-fluorophenyl)phenyl]ethanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. 登録日 2023-09-11 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
8WCA	Cryo-EM structure of the PEA-bound hTAAR1-Gs complex 分子名称: 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. 登録日 2023-09-11 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.48 Å) 主引用文献 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
8WCB	Cryo-EM structure of the CHA-bound mTAAR1-Gq complex 分子名称: CYCLOHEXYLAMMONIUM ION, Engineered G-alpha-q subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. 登録日 2023-09-11 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
8WC8	Cryo-EM structure of the ZH8651-bound hTAAR1-Gs complex 分子名称: 2-(4-bromophenyl)ethanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. 登録日 2023-09-11 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
8WC3	Cryo-EM structure of the SEP363856-bound mTAAR1-Gs complex 分子名称: 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. 登録日 2023-09-11 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
8WC5	Cryo-EM structure of the TMA-bound mTAAR1-Gs complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. 登録日 2023-09-11 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
8WC4	Cryo-EM structure of the ZH8651-bound mTAAR1-Gs complex 分子名称: 2-(4-bromophenyl)ethanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. 登録日 2023-09-11 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
8WC9	Cryo-EM structure of the ZH8651-bound mTAAR1-Gq complex 分子名称: 2-(4-bromophenyl)ethanamine, Engineered G-alpha-q subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. 登録日 2023-09-11 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
8WC6	Cryo-EM structure of the PEA-bound mTAAR1-Gs complex 分子名称: 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. 登録日 2023-09-11 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
8WCC	Cryo-EM structure of the CHA-bound mTAAR1 complex 分子名称: CYCLOHEXYLAMMONIUM ION, Trace amine-associated receptor 1 著者 Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. 登録日 2023-09-11 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
4Q8F	Human DNA polymerase eta extending primer immediately after a phenanthriplatin adducted G 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, 5'-D(*AP*GP*TP*GP*TP*GP*AP*C)-3', 5'-D(*CP*AP*TP*CP*GP*TP*CP*AP*CP*AP*CP*T)-3', ... 著者 Gregory, M.T, Yang, W. 登録日 2014-04-26 公開日 2014-07-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.797 Å) 主引用文献 Structural and mechanistic studies of polymerase eta bypass of phenanthriplatin DNA damage. Proc.Natl.Acad.Sci.USA, 111, 2014
4Q8E	Human DNA polymerase eta inserting dCMPNPP opposite a phenanthriplatin adducted G 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, 5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3', 5'-D(*CP*AP*TP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3', ... 著者 Gregory, M.T, Yang, W. 登録日 2014-04-26 公開日 2014-07-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.549 Å) 主引用文献 Structural and mechanistic studies of polymerase eta bypass of phenanthriplatin DNA damage. Proc.Natl.Acad.Sci.USA, 111, 2014
3ZBF	Structure of Human ROS1 Kinase Domain in Complex with Crizotinib 分子名称: 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS 著者 McTigue, M, Deng, Y, Liu, W, Brooun, A, Stewart, A. 登録日 2012-11-08 公開日 2013-06-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Acquired Resistance to Crizotinib from a Mutation in Cd74-Ros1 N.Engl.J.Med., 368, 2013
4RSO	The structure of the neurotropic AAVrh.8 viral vector 分子名称: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, CHLORIDE ION, Capsid protein VP1, ... 著者 Halder, S, Van Vliet, K, Smith, J.K, McKenna, R, Wilson, J.M, Agbandje-McKenna, M. 登録日 2014-11-10 公開日 2016-04-13 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structure of neurotropic adeno-associated virus AAVrh.8. J.Struct.Biol., 192, 2015
4P08	Engineered thermostable dimeric cocaine esterase 分子名称: Cocaine esterase 著者 Rodgers, D.W, Chow, K.-M, Fang, L, Zhan, C.-G. 登録日 2014-02-20 公開日 2014-07-16 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.341 Å) 主引用文献 Rational design, preparation, and characterization of a therapeutic enzyme mutant with improved stability and function for cocaine detoxification. Acs Chem.Biol., 9, 2014

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