4P08
Engineered thermostable dimeric cocaine esterase
Summary for 4P08
| Entry DOI | 10.2210/pdb4p08/pdb |
| Descriptor | Cocaine esterase (2 entities in total) |
| Functional Keywords | esterase, disulfide-linked dimer, cocaine, mutant, hydrolase |
| Biological source | Rhodococcus sp. |
| Total number of polymer chains | 1 |
| Total formula weight | 61945.08 |
| Authors | Rodgers, D.W.,Chow, K.-M.,Fang, L.,Zhan, C.-G. (deposition date: 2014-02-20, release date: 2014-07-16, Last modification date: 2023-12-27) |
| Primary citation | Fang, L.,Chow, K.M.,Hou, S.,Xue, L.,Chen, X.,Rodgers, D.W.,Zheng, F.,Zhan, C.G. Rational design, preparation, and characterization of a therapeutic enzyme mutant with improved stability and function for cocaine detoxification. Acs Chem.Biol., 9:1764-1772, 2014 Cited by PubMed: 24919140DOI: 10.1021/cb500257s PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.341 Å) |
Structure validation
Download full validation report
