3ZBF
Structure of Human ROS1 Kinase Domain in Complex with Crizotinib
Summary for 3ZBF
Entry DOI | 10.2210/pdb3zbf/pdb |
Descriptor | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine (3 entities in total) |
Functional Keywords | transferase, tyrosine kinase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 37464.82 |
Authors | McTigue, M.,Deng, Y.,Liu, W.,Brooun, A.,Stewart, A. (deposition date: 2012-11-08, release date: 2013-06-12, Last modification date: 2023-12-20) |
Primary citation | Awad, M.M.,Katayama, R.,Mctigue, M.,Liu, W.,Deng, Y.,Brooun, A.,Friboulet, L.,Huang, D.,Falk, M.D.,Timofeevski, S.,Wilner, K.D.,Lockerman, E.L.,Khan, T.M.,Mahmood, S.,Gainor, J.F.,Digumarthy, S.R.,Stone, J.R.,Mino-Kenudson, M.,Christensen, J.G.,Iafrate, J.,Engelman, J.A.,Shaw, A.T. Acquired Resistance to Crizotinib from a Mutation in Cd74-Ros1 N.Engl.J.Med., 368:2395-, 2013 Cited by PubMed: 23724914DOI: 10.1056/NEJMOA1215530 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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