PDB: 2356 件ウェブページステータス検索Chemie searchBIRD

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3AC3	Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) 分子名称: 2-[(3,5-dimethoxyphenyl)amino]-5-ethyl-7-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION 著者 Tsuji, E. 登録日 2009-12-28 公開日 2010-06-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published
3AC2	Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(2-amino-2-methylpropyl)amino]-2-[(3,5-dimethoxyphenyl)amino]-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide, DIMETHYL SULFOXIDE, ... 著者 Tsuji, E. 登録日 2009-12-28 公開日 2010-06-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published
3AC1	Crystal structure of pyrazin derivative bound to the kinase domain of Human LCK, (Auto-phosphorylated on TYR394) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-[(3,5-dimethoxyphenyl)amino]pyrazine-2-carboxamide, DIMETHYL SULFOXIDE, ... 著者 Tsuji, E. 登録日 2009-12-28 公開日 2010-06-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published
3A4P	human c-MET kinase domain complexed with 6-benzyloxyquinoline inhibitor 分子名称: (2E)-3-{6-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl}-N-methylprop-2-enamide, CHLORIDE ION, Hepatocyte growth factor receptor, ... 著者 Fukami, T.A, Kadono, S, Yamamuro, M, Matsuura, T. 登録日 2009-07-13 公開日 2010-02-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors Bioorg.Med.Chem.Lett., 20, 2010
3A4O	Lyn kinase domain 分子名称: STAUROSPORINE, Tyrosine-protein kinase Lyn 著者 Miyano, N, Kinoshita, T, Tada, T. 登録日 2009-07-11 公開日 2009-12-08 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis for the inhibitor recognition of human Lyn kinase domain Bioorg.Med.Chem.Lett., 19, 2009
2ZYB	Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) 分子名称: N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine, Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION 著者 Tsuji, E. 登録日 2009-01-19 公開日 2009-02-03 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase Bioorg.Med.Chem., 16, 2008
2ZVA	Lyn Tyrosine Kinase Domain-Dasatinib complex 分子名称: N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Tyrosine-protein kinase Lyn 著者 Williams, N.K, Rossjohn, J. 登録日 2008-11-04 公開日 2008-11-11 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its Apo- and Inhibitor-bound State J.Biol.Chem., 284, 2009
2ZV9	Lyn Tyrosine Kinase Domain-PP2 complex 分子名称: 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, Tyrosine-protein kinase Lyn 著者 Williams, N.K, Rossjohn, J. 登録日 2008-11-04 公開日 2008-11-11 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Crystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its Apo- and Inhibitor-bound State J.Biol.Chem., 284, 2009
2ZV8	Lyn Tyrosine Kinase Domain-AMP-PNP complex 分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase Lyn 著者 Williams, N.K, Rossjohn, J. 登録日 2008-11-04 公開日 2008-11-11 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its Apo- and Inhibitor-bound State J.Biol.Chem., 284, 2009
2ZV7	Lyn Tyrosine Kinase Domain, apo form 分子名称: Tyrosine-protein kinase Lyn 著者 Williams, N.K, Rossjohn, J. 登録日 2008-11-04 公開日 2008-11-11 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its Apo- and Inhibitor-bound State J.Biol.Chem., 284, 2009
2ZM4	Crystal structure of imidazo quinoxaline 1 bound to the kinase domain of human LCK, activated form (auto-phosphorylated on TYR394) 分子名称: DIMETHYL SULFOXIDE, N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine, Proto-oncogene tyrosine-protein kinase LCK, ... 著者 Tsuji, E. 登録日 2008-04-11 公開日 2008-10-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase Bioorg.Med.Chem., 16, 2008
2ZM3	Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor 分子名称: (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione, Insulin-like growth factor 1 receptor 著者 Xu, W, Mayer, S.C, Boschelli, F, Johnson, M, Dwyer, B. 登録日 2008-04-10 公開日 2008-06-10 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment Bioorg.Med.Chem.Lett., 18, 2008
2ZM1	Crystal structure of imidazo pyrazin 1 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) 分子名称: DIMETHYL SULFOXIDE, N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine, Proto-oncogene tyrosine-protein kinase LCK, ... 著者 Tsuji, E. 登録日 2008-04-10 公開日 2008-10-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase Bioorg.Med.Chem., 16, 2008
2Z8C	Phosphorylated insulin receptor tyrosine kinase in complex with (4-{[5-carbamoyl-4-(3-methylanilino)pyrimidin-2-yl]amino}phenyl)acetic acid 分子名称: 6-mer peptide from Insulin receptor substrate 1, Insulin receptor, [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID 著者 Katayama, N, Kurihara, H. 登録日 2007-09-05 公開日 2008-08-12 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors. Proteins, 73, 2008
2Z60	Crystal Structure of the T315I Mutant of Abl kinase bound with PPY-A 分子名称: 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE, Proto-oncogene tyrosine-protein kinase ABL1 著者 Zhou, T, Dalgarno, D, Zhu, X. 登録日 2007-07-21 公開日 2007-09-18 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal Structure of the T315I Mutant of Abl Kinase Chem.Biol.Drug Des., 70, 2007
2YN8	ephB4 kinase domain inhibitor complex 分子名称: EPHRIN TYPE-B RECEPTOR 4, STAUROSPORINE 著者 Read, J, Brassington, C.A, Overmann, R. 登録日 2012-10-13 公開日 2013-10-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Stability and Solubility Engineering of the Ephb4 Tyrosine Kinase Catalytic Domain Using a Rationally Designed Synthetic Library. Protein Eng.Des.Sel., 26, 2013
2YJS	Structure of C1156Y Mutant Anaplastic Lymphoma Kinase 分子名称: ALK TYROSINE KINASE RECEPTOR 著者 McTigue, M, Deng, Y, Liu, W, Brooun, A. 登録日 2011-05-23 公開日 2012-06-06 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of C1156Y Mutant Anaplastic Lymphoma Kinase To be Published
2YJR	Structure of F1174L Mutant Anaplastic Lymphoma Kinase 分子名称: ALK TYROSINE KINASE RECEPTOR 著者 McTigue, M, Deng, Y, Liu, W, Brooun, A. 登録日 2011-05-23 公開日 2012-06-06 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of F1174L Mutant Anaplastic Lymphoma Kinase To be Published
2YIY	Crystal structure of compound 8 bound to TAK1-TAB 分子名称: (1E)-1-[5-TERT-BUTYL-2-(3-FLUOROPHENYL)-1H-PYRAZOL-3-YLIDENE]-3-(4-PYRIDIN-3-YLOXYPHENYL)UREA, MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7, TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1 著者 Brown, D.G, Phillips, C. 登録日 2011-05-17 公開日 2012-05-23 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 The Discovery and Synthesis of Selective Dfg-Out Tak-1 Inhibitors To be Published
2YHV	Structure of L1196M Mutant Anaplastic Lymphoma Kinase 分子名称: ALK TYROSINE KINASE RECEPTOR 著者 McTigue, M, Deng, Y, Liu, W, Brooun, A. 登録日 2011-05-06 公開日 2011-05-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib. J.Med.Chem., 57, 2014
2YFX	Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib 分子名称: 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, TYROSINE-PROTEIN KINASE RECEPTOR 著者 McTigue, M, Deng, Y, Liu, W, Brooun, A. 登録日 2011-04-08 公開日 2011-05-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib. J.Med.Chem., 57, 2014
2Y6O	Crystal structure of EphA4 kinase domain in complex with Dasatinib. 分子名称: EPHRIN TYPE-A RECEPTOR 4, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE 著者 Farenc, C.J.A, Celie, P.H.N, Siegal, G. 登録日 2011-01-25 公開日 2011-11-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.543 Å) 主引用文献 Crystal Structure of the Epha4 Protein Tyrosine Kinase Domain in the Apo- and Dasatinib-Bound State. FEBS Lett., 585, 2011
2Y6M	Crystal structure of EphA4 kinase domain 分子名称: EPHRIN TYPE-A RECEPTOR 4, GLYCEROL 著者 Farenc, C.J.A, Celie, P.H.N, Siegal, G. 登録日 2011-01-25 公開日 2011-11-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structure of the Epha4 Protein Tyrosine Kinase Domain in the Apo- and Dasatinib-Bound State. FEBS Lett., 585, 2011
2Y4I	KSR2-MEK1 heterodimer 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, ... 著者 Brennan, D.F, Barford, D. 登録日 2011-01-06 公開日 2011-01-19 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.46 Å) 主引用文献 A Raf-Induced Allosteric Transition of Ksr Stimulates Ksr and Raf Phosphorylation of Mek Nature, 472, 2011
2XYU	Crystal structure of EphA4 kinase domain in complex with VUF 12058 分子名称: 5-(5-FLUORO-2-METHYLPHENYL)-6,7,8,9-TETRAHYDRO-3H-PYRAZOLO[3,4-C]ISOQUINOLIN-1-AMINE, EPHRIN TYPE-A RECEPTOR 4,, GLYCEROL 著者 Farenc, C.J.A, Celie, P.H.N, vanLinden, O.P.J, Siegal, G. 登録日 2010-11-19 公開日 2011-11-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.117 Å) 主引用文献 Fragment Based Lead Discovery of Small Molecule Inhibitors for the Epha4 Receptor Tyrosine Kinase. Eur.J.Med.Chem., 47, 2012

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