2Z8C
Phosphorylated insulin receptor tyrosine kinase in complex with (4-{[5-carbamoyl-4-(3-methylanilino)pyrimidin-2-yl]amino}phenyl)acetic acid
Summary for 2Z8C
Entry DOI | 10.2210/pdb2z8c/pdb |
Related | 2Z7L |
Descriptor | Insulin receptor, 6-mer peptide from Insulin receptor substrate 1, [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID (3 entities in total) |
Functional Keywords | transferase, alternative splicing, atp-binding, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphorylation, polymorphism, receptor, transmembrane, tyrosine-protein kinase, transducer |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein: P06213 |
Total number of polymer chains | 2 |
Total formula weight | 35826.57 |
Authors | Katayama, N.,Kurihara, H. (deposition date: 2007-09-05, release date: 2008-08-12, Last modification date: 2023-11-15) |
Primary citation | Katayama, N.,Orita, M.,Yamaguchi, T.,Hisamichi, H.,Kuromitsu, S.,Kurihara, H.,Sakashita, H.,Matsumoto, Y.,Fujita, S.,Niimi, T. Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors. Proteins, 73:795-801, 2008 Cited by PubMed: 18767165DOI: 10.1002/prot.22207 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.25 Å) |
Structure validation
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