2Z8C
Phosphorylated insulin receptor tyrosine kinase in complex with (4-{[5-carbamoyl-4-(3-methylanilino)pyrimidin-2-yl]amino}phenyl)acetic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin receptor | polymer | 303 | 34689.3 | 1 | UniProt (P06213) Pfam (PF07714) | Homo sapiens (Human) | IR, CD220 ANTIGEN |
| 2 | B (B) | 6-mer peptide from Insulin receptor substrate 1 | polymer | 6 | 759.8 | 1 | UniProt (P35568) | Homo sapiens (Human) | IRS-1 |
| 3 | C (A) | [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID | non-polymer | 377.4 | 1 | Chemie (S91) |
Sequence modifications
A: 981 - 1283 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| Ser 981 | Cys 1008 | engineered mutation |
| Phe 984 | Tyr 1011 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35449.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 377.4 | |
| All* | Total formula weight | 35826.6 |
