2YIY

Crystal structure of compound 8 bound to TAK1-TAB

Summary for 2YIY

• Entry DOI: 10.2210/pdb2yiy/pdb
• Related: 2EVA 2J4O
• Descriptor: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7, TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1, (1E)-1-[5-TERT-BUTYL-2-(3-FLUOROPHENYL)-1H-PYRAZOL-3-YLIDENE]-3-(4-PYRIDIN-3-YLOXYPHENYL)UREA (3 entities in total)
• Functional Keywords: transferase-transferase activator complex, tak-tab kinase dfg-out, transferase/transferase activator
• Biological source: HOMO SAPIENS
• Total number of polymer chains: 1
• Total formula weight: 35226.59

Authors

Brown, D.G.,Phillips, C. (deposition date: 2011-05-17, release date: 2012-05-23, Last modification date: 2023-12-20)

• Primary citation: Green, M.P.,Bell, A.,Bess, K.,Brown, D.G.,Campany, K.,Dodd, P.,Hewson, C.,Hughes, S.J.,Kilty, I.,Phillips, C.,Smith, R.T.,Hoorn, W.V.,Jones, L.; The Discovery and Synthesis of Selective Dfg-Out Tak-1 Inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (2.49 Å)