2YIY
Crystal structure of compound 8 bound to TAK1-TAB
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7, TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1 | polymer | 307 | 34781.1 | 1 | UniProt (O43318) UniProt (Q15750) Pfam (PF07714) | HOMO SAPIENS | TRANSFORMING GROWTH FACTOR-BETA-ACTIVATED KINASE 1 TGF-BETA- ACTIVATED KINASE 1, PROTEIN KINASE TRANSFORMING GROWTH FACTOR ACTIVATED KINASE 1 TAK-1 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 1, TGF-BETA-ACTIVATED KINASE 1- BINDING PROTEIN 1, TAK1-BINDING PROTEIN 1 |
| 2 | B (A) | (1E)-1-[5-TERT-BUTYL-2-(3-FLUOROPHENYL)-1H-PYRAZOL-3-YLIDENE]-3-(4-PYRIDIN-3-YLOXYPHENYL)UREA | non-polymer | 445.5 | 1 | Chemie (YIY) | |||
| 3 | C (A) | water | water | 18.0 | 213 | Chemie (HOH) |
Sequence modifications
A: 31 - 303 (UniProt: O43318)
A: 468 - 497 (UniProt: Q15750)
| PDB | External Database | Details |
|---|---|---|
| Ser 27 | - | expression tag |
| Leu 28 | - | expression tag |
| His 29 | - | expression tag |
| Met 30 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34781.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 445.5 | |
| All* | Total formula weight | 35226.6 |
