2XYU
Crystal structure of EphA4 kinase domain in complex with VUF 12058
Summary for 2XYU
Entry DOI | 10.2210/pdb2xyu/pdb |
Related | 1B0X |
Descriptor | EPHRIN TYPE-A RECEPTOR 4,, GLYCEROL, 5-(5-FLUORO-2-METHYLPHENYL)-6,7,8,9-TETRAHYDRO-3H-PYRAZOLO[3,4-C]ISOQUINOLIN-1-AMINE, ... (4 entities in total) |
Functional Keywords | signaling protein, transferase |
Biological source | MUS MUSCULUS (MOUSE) |
Cellular location | Cell membrane; Single-pass type I membrane protein: Q03137 |
Total number of polymer chains | 1 |
Total formula weight | 33081.23 |
Authors | Farenc, C.J.A.,Celie, P.H.N.,vanLinden, O.P.J.,Siegal, G. (deposition date: 2010-11-19, release date: 2011-11-30, Last modification date: 2023-12-20) |
Primary citation | Van Linden, O.P.,Farenc, C.J.A.,Zoutman, W.H.,Hameetman, L.,Wijtmans, M.,Leurs, R.,Tensen, C.P.,Siegal, G.,De Esch, I.J. Fragment Based Lead Discovery of Small Molecule Inhibitors for the Epha4 Receptor Tyrosine Kinase. Eur.J.Med.Chem., 47:493-, 2012 Cited by PubMed: 22137457DOI: 10.1016/J.EJMECH.2011.11.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.117 Å) |
Structure validation
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