2Y6O

Crystal structure of EphA4 kinase domain in complex with Dasatinib.

Summary for 2Y6O

Entry DOI	10.2210/pdb2y6o/pdb
Related	1B0X 2XYU 2Y6M
Descriptor	EPHRIN TYPE-A RECEPTOR 4, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (3 entities in total)
Functional Keywords	signalling protein, transferase
Biological source	MUS MUSCULUS (HOUSE MOUSE)
Cellular location	Cell membrane; Single-pass type I membrane protein: Q03137
Total number of polymer chains	1
Total formula weight	33419.08
Authors	Farenc, C.J.A.,Celie, P.H.N.,Siegal, G. (deposition date: 2011-01-25, release date: 2011-11-02, Last modification date: 2023-12-20)
Primary citation	Farenc, C.J.A.,Hameetman, L.,Zoutman, W.,Tensen, C.P.,Siegal, G. Crystal Structure of the Epha4 Protein Tyrosine Kinase Domain in the Apo- and Dasatinib-Bound State. FEBS Lett., 585:3593-, 2011 Cited by PubMed: 22036717 DOI: 10.1016/J.FEBSLET.2011.10.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.543 Å)

Structure validation