3A4P

human c-MET kinase domain complexed with 6-benzyloxyquinoline inhibitor

Summary for 3A4P

Entry DOI	10.2210/pdb3a4p/pdb
Related	1r1w 2wgj
Descriptor	Hepatocyte growth factor receptor, CHLORIDE ION, ISOPROPYL ALCOHOL, ... (5 entities in total)
Functional Keywords	c-met, tyrosine-protein kinase, hepatocyte growth factor receptor, transferase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
Total number of polymer chains	1
Total formula weight	36562.61
Authors	Fukami, T.A.,Kadono, S.,Yamamuro, M.,Matsuura, T. (deposition date: 2009-07-13, release date: 2010-02-16, Last modification date: 2023-11-01)
Primary citation	Nishii, H.,Chiba, T.,Morikami, K.,Fukami, T.A.,Sakamoto, H.,Ko, K.,Koyano, H. Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors Bioorg.Med.Chem.Lett., 20:1405-1409, 2010 Cited by PubMed: 20093027 DOI: 10.1016/j.bmcl.2009.12.109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.54 Å)

Structure validation