3A4P
human c-MET kinase domain complexed with 6-benzyloxyquinoline inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte growth factor receptor | polymer | 319 | 35987.7 | 1 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | HGF receptor, Scatter factor receptor, SF receptor, HGF/SF receptor, Met proto-oncogene tyrosine kinase, c-Met |
| 2 | B (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | C, D (A) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 2 | Chemie (IPA) | |||
| 4 | E (A) | (2E)-3-{6-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl}-N-methylprop-2-enamide | non-polymer | 419.3 | 1 | Chemie (DFQ) | |||
| 5 | F (A) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A: 1049 - 1360 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Gly 1042 | - | expression tag |
| Pro 1043 | - | expression tag |
| Leu 1044 | - | expression tag |
| His 1045 | - | expression tag |
| Met 1046 | - | expression tag |
| Gly 1047 | - | expression tag |
| Ser 1048 | - | expression tag |
| Phe 1194 | Tyr 1194 | engineered mutation |
| Phe 1234 | Tyr 1234 | engineered mutation |
| Asp 1235 | Tyr 1235 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35987.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 574.9 | |
| All* | Total formula weight | 36562.6 |
