3A4P
human c-MET kinase domain complexed with 6-benzyloxyquinoline inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Hepatocyte growth factor receptor | polymer | 319 | 35987.7 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (human) | HGF receptor, Scatter factor receptor, SF receptor, HGF/SF receptor, Met proto-oncogene tyrosine kinase, c-Met |
2 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
3 | A | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 2 | Chemie (IPA) | |||
4 | A | (2E)-3-{6-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl}-N-methylprop-2-enamide | non-polymer | 419.3 | 1 | Chemie (DFQ) | |||
5 | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A: 1049 - 1360 (UniProt: P08581)
PDB | External Database | Details |
---|---|---|
Gly 1042 | - | expression tag |
Pro 1043 | - | expression tag |
Leu 1044 | - | expression tag |
His 1045 | - | expression tag |
Met 1046 | - | expression tag |
Gly 1047 | - | expression tag |
Ser 1048 | - | expression tag |
Phe 1194 | Tyr 1194 | engineered mutation |
Phe 1234 | Tyr 1234 | engineered mutation |
Asp 1235 | Tyr 1235 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35987.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 574.9 | |
All* | Total formula weight | 36562.6 |