8QUJ
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![BU of 8quj by Molmil](/molmil-images/mine/8quj) | Hexameric HIV-1 CA in complex with DDD00100452 | 分子名称: | 1,2-ETHANEDIOL, 3-(phenylmethyl)-1~{H}-imidazol-2-one, Spacer peptide 1 | 著者 | Petit, A.P, Fyfe, P.K. | 登録日 | 2023-10-16 | 公開日 | 2024-03-27 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV-CA Binding Fragments. Chemmedchem, 19, 2024
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6CCX
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![BU of 6ccx by Molmil](/molmil-images/mine/6ccx) | NMR data-driven model of GTPase KRas-GMPPNP:Cmpd2 complex tethered to a nanodisc | 分子名称: | (2R,4S)-4-[(5-bromo-1H-indole-3-carbonyl)amino]-2-[(4-chlorophenyl)methyl]piperidin-1-ium, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, ... | 著者 | Fang, Z, Marshall, C.B, Nishikawa, T, Gossert, A.D, Jansen, J.M, Jahnke, W, Ikura, M. | 登録日 | 2018-02-07 | 公開日 | 2018-09-05 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site. Cell Chem Biol, 25, 2018
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6UDO
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![BU of 6udo by Molmil](/molmil-images/mine/6udo) | Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Fully compressed filament segment reconstruction. | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | 著者 | Johnson, M.C, Kollman, J.M. | 登録日 | 2019-09-19 | 公開日 | 2020-03-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, 2020
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5LP5
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![BU of 5lp5 by Molmil](/molmil-images/mine/5lp5) | Complex between Penicillin-Binding Protein (PBP2) and MreC from Helicobacter pylori | 分子名称: | Penicillin-binding protein 2 (Pbp2), Rod shape-determining protein (MreC) | 著者 | Contreras-Martel, C, Martins, A, Ecobichon, C, Maragno, D.M, Mattei, P.J, El Ghachi, M, Hicham, S, Hardouin, P, Boneca, I.G, Dessen, A. | 登録日 | 2016-08-11 | 公開日 | 2017-08-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Molecular architecture of the PBP2-MreC core bacterial cell wall synthesis complex. Nat Commun, 8, 2017
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8QUD
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![BU of 8qud by Molmil](/molmil-images/mine/8qud) | Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT5 | 分子名称: | (5R)-5-ethyl-3-(6-spiro[2H-1-benzofuran-3,1'-cyclopropane]-4-yloxypyridin-3-yl)imidazolidine-2,4-dione, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Chi, G, Mckinley, G, Marsden, B, Pike, A.C.W, Ye, M, Brooke, L.M, Bakshi, S, Lakshminarayana, B, Pilati, N, Marasco, A, Gunthorpe, M, Alvaro, G.S, Large, C.H, Williams, E, Sauer, D.B. | 登録日 | 2023-10-16 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | The binding and mechanism of a positive allosteric modulator of Kv3 channels. Nat Commun, 15, 2024
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6CCH
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![BU of 6cch by Molmil](/molmil-images/mine/6cch) | NMR data-driven model of GTPase KRas-GMPPNP tethered to a nanodisc (E3 state) | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, GTPase KRas, ... | 著者 | Fang, Z, Marshall, C.B, Nishikawa, T, Gossert, A.D, Jansen, J.M, Jahnke, W, Ikura, M. | 登録日 | 2018-02-07 | 公開日 | 2018-08-29 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site. Cell Chem Biol, 25, 2018
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5I2C
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![BU of 5i2c by Molmil](/molmil-images/mine/5i2c) | |
7JN4
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![BU of 7jn4 by Molmil](/molmil-images/mine/7jn4) | Rubisco in the apo state | 分子名称: | Ribulose bisphosphate carboxylase large chain, Ribulose bisphosphate carboxylase small chain 2, chloroplastic | 著者 | Matthies, D, Jonikas, M.C, He, S. | 登録日 | 2020-08-03 | 公開日 | 2020-11-18 | 最終更新日 | 2020-12-23 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | The structural basis of Rubisco phase separation in the pyrenoid. Nat.Plants, 6, 2020
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6JEO
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![BU of 6jeo by Molmil](/molmil-images/mine/6jeo) | Structure of PSI tetramer from Anabaena | 分子名称: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, BETA-CAROTENE, ... | 著者 | Kato, K, Nagao, R, Shen, J.R, Miyazaki, N, Akita, F. | 登録日 | 2019-02-06 | 公開日 | 2019-11-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of a cyanobacterial photosystem I tetramer revealed by cryo-electron microscopy. Nat Commun, 10, 2019
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6W1N
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6ONT
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![BU of 6ont by Molmil](/molmil-images/mine/6ont) | Structure of the Francisella response regulator 1452 receiver domain | 分子名称: | CALCIUM ION, CHLORIDE ION, SODIUM ION, ... | 著者 | Milton, M.E, Cavanagh, J. | 登録日 | 2019-04-22 | 公開日 | 2020-03-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | 主引用文献 | Francisella novicidaTwo-Component System Response Regulator BfpR Modulates iglC Gene Expression, Antimicrobial Peptide Resistance, and Biofilm Production. Front Cell Infect Microbiol, 10, 2020
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6DA1
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![BU of 6da1 by Molmil](/molmil-images/mine/6da1) | ETS1 in complex with synthetic SRR mimic | 分子名称: | Protein C-ets-1, SULFATE ION, serine-rich region (SRR) peptide | 著者 | Perez-Borrajero, C, Okon, M, Lin, C.S, Scheu, K, Murphy, M.E.P, Graves, B.J, McIntosh, L.P. | 登録日 | 2018-05-01 | 公開日 | 2019-01-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.000127 Å) | 主引用文献 | The Biophysical Basis for Phosphorylation-Enhanced DNA-Binding Autoinhibition of the ETS1 Transcription Factor. J. Mol. Biol., 431, 2019
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7JRG
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![BU of 7jrg by Molmil](/molmil-images/mine/7jrg) | Plant Mitochondrial complex III2 from Vigna radiata | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Alpha-MPP, ... | 著者 | Maldonado, M, Letts, J.A. | 登録日 | 2020-08-12 | 公開日 | 2021-01-20 | 最終更新日 | 2021-02-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Atomic structures of respiratory complex III 2 , complex IV, and supercomplex III 2 -IV from vascular plants. Elife, 10, 2021
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6W4H
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![BU of 6w4h by Molmil](/molmil-images/mine/6w4h) | 1.80 Angstrom Resolution Crystal Structure of NSP16 - NSP10 Complex from SARS-CoV-2 | 分子名称: | 2'-O-methyltransferase, ACETATE ION, Non-structural protein 10, ... | 著者 | Minasov, G, Shuvalova, L, Rosas-Lemus, M, Kiryukhina, O, Wiersum, G, Godzik, A, Jaroszewski, L, Stogios, P.J, Skarina, T, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-03-10 | 公開日 | 2020-03-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | High-resolution structures of the SARS-CoV-2 2'- O -methyltransferase reveal strategies for structure-based inhibitor design. Sci.Signal., 13, 2020
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6O0L
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![BU of 6o0l by Molmil](/molmil-images/mine/6o0l) | crystal structure of BCL-2 G101V mutation with venetoclax | 分子名称: | 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2, CHLORIDE ION, ... | 著者 | Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E. | 登録日 | 2019-02-16 | 公開日 | 2019-05-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations. Nat Commun, 10, 2019
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6O0P
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![BU of 6o0p by Molmil](/molmil-images/mine/6o0p) | crystal structure of BCL-2 G101A mutation with venetoclax | 分子名称: | 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2, DI(HYDROXYETHYL)ETHER | 著者 | Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E. | 登録日 | 2019-02-17 | 公開日 | 2019-05-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations. Nat Commun, 10, 2019
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7K2T
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6C97
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![BU of 6c97 by Molmil](/molmil-images/mine/6c97) | Crystal structure of FcRn at pH3 | 分子名称: | Beta-2-microglobulin, GLYCEROL, IgG receptor FcRn large subunit p51 | 著者 | Fox III, D, Fairman, J.W. | 登録日 | 2018-01-25 | 公開日 | 2018-05-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR. PLoS Biol., 16, 2018
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6J65
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![BU of 6j65 by Molmil](/molmil-images/mine/6j65) | Crystal structure of human HINT1 mutant complexing with AP4A II | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, Histidine triad nucleotide-binding protein 1 | 著者 | Wang, J, Fang, P, Guo, M. | 登録日 | 2019-01-14 | 公開日 | 2019-09-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells. Nat Commun, 10, 2019
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6VKM
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![BU of 6vkm by Molmil](/molmil-images/mine/6vkm) | Crystal Structure of Stabilized GP from Makona Variant of Ebola Virus | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Virion spike glycoprotein | 著者 | Gilman, M.S.A, Rutten, L, Langedijk, J.P.M, McLellan, J.S. | 登録日 | 2020-01-21 | 公開日 | 2020-04-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers. Cell Rep, 30, 2020
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1GUO
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![BU of 1guo by Molmil](/molmil-images/mine/1guo) | |
6VME
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![BU of 6vme by Molmil](/molmil-images/mine/6vme) | Human ESCRT-I heterotetramer headpiece | 分子名称: | Multivesicular body subunit 12A, Tumor susceptibility gene 101 protein, Vacuolar protein sorting-associated protein 28 homolog, ... | 著者 | Flower, T.G, Hurley, J.H, Tjahjono, N. | 登録日 | 2020-01-27 | 公開日 | 2020-05-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission. Nat.Struct.Mol.Biol., 27, 2020
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6JZB
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6U7L
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![BU of 6u7l by Molmil](/molmil-images/mine/6u7l) | 2.75 Angstrom Crystal Structure of Galactarate Dehydratase from Escherichia coli. | 分子名称: | CALCIUM ION, CHLORIDE ION, Galactarate dehydratase (L-threo-forming) | 著者 | Minasov, G, Shuvalova, L, Wawrzak, Z, Dubrovska, I, Kiryukhina, O, Endres, M, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2019-09-03 | 公開日 | 2019-11-06 | 最終更新日 | 2021-01-27 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structure of galactarate dehydratase, a new fold in an enolase involved in bacterial fitness after antibiotic treatment. Protein Sci., 29, 2020
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7JOY
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![BU of 7joy by Molmil](/molmil-images/mine/7joy) | |