6UDO

Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Fully compressed filament segment reconstruction.

Summary for 6UDO

Entry DOI	10.2210/pdb6udo/pdb
Related	6U8E 6U8N 6U8R 6U8S 6U9O 6UA2 6UA4 6UA5 6UAJ 6UC2
EMDB information	20687 20688 20690 20691 20701 20704 20705 20706 20707 20709 20716 20718 20720 20722 20723 20725 20741
Descriptor	Inosine-5'-monophosphate dehydrogenase 2, INOSINIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
Functional Keywords	metabolism, filament, allostery, adenine, guanine, biosynthetic protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	16
Total formula weight	918901.98
Authors	Johnson, M.C.,Kollman, J.M. (deposition date: 2019-09-19, release date: 2020-03-25, Last modification date: 2024-03-20)
Primary citation	Johnson, M.C.,Kollman, J.M. Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9:-, 2020 Cited by PubMed: 31999252 DOI: 10.7554/eLife.53243 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.21 Å)

Structure validation