8QUD

Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT5

Summary for 8QUD

Entry DOI	10.2210/pdb8qud/pdb
EMDB information	18659 18660
Descriptor	Potassium voltage-gated channel subfamily C member 1, (5R)-5-ethyl-3-(6-spiro[2H-1-benzofuran-3,1'-cyclopropane]-4-yloxypyridin-3-yl)imidazolidine-2,4-dione, ZINC ION, ... (7 entities in total)
Functional Keywords	modulator, homotetramer, voltage-gated potassium channel, membrane protein, kv3.1, kcnc1
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	242241.13
Authors	Chi, G.,Mckinley, G.,Marsden, B.,Pike, A.C.W.,Ye, M.,Brooke, L.M.,Bakshi, S.,Lakshminarayana, B.,Pilati, N.,Marasco, A.,Gunthorpe, M.,Alvaro, G.S.,Large, C.H.,Williams, E.,Sauer, D.B. (deposition date: 2023-10-16, release date: 2024-04-03)
Primary citation	Liang, Q.,Chi, G.,Cirqueira, L.,Zhi, L.,Marasco, A.,Pilati, N.,Gunthorpe, M.J.,Alvaro, G.,Large, C.H.,Sauer, D.B.,Treptow, W.,Covarrubias, M. The binding and mechanism of a positive allosteric modulator of Kv3 channels. Nat Commun, 15:2533-2533, 2024 Cited by PubMed: 38514618 DOI: 10.1038/s41467-024-46813-8 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.5 Å)

Structure validation