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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8QUD

Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT5

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0005216molecular_functionmonoatomic ion channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005251molecular_functiondelayed rectifier potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0008076cellular_componentvoltage-gated potassium channel complex
A0009636biological_processresponse to toxic substance
A0009642biological_processresponse to light intensity
A0009986cellular_componentcell surface
A0010996biological_processresponse to auditory stimulus
A0014075biological_processresponse to amine
A0016020cellular_componentmembrane
A0019894molecular_functionkinesin binding
A0021549biological_processcerebellum development
A0021554biological_processoptic nerve development
A0021759biological_processglobus pallidus development
A0022038biological_processcorpus callosum development
A0022836molecular_functiongated channel activity
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030673cellular_componentaxolemma
A0032589cellular_componentneuron projection membrane
A0032590cellular_componentdendrite membrane
A0032809cellular_componentneuronal cell body membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0034765biological_processregulation of monoatomic ion transmembrane transport
A0034767biological_processpositive regulation of monoatomic ion transmembrane transport
A0035864biological_processresponse to potassium ion
A0042734cellular_componentpresynaptic membrane
A0042995cellular_componentcell projection
A0043025cellular_componentneuronal cell body
A0043679cellular_componentaxon terminus
A0044305cellular_componentcalyx of Held
A0044325molecular_functiontransmembrane transporter binding
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0051260biological_processprotein homooligomerization
A0051262biological_processprotein tetramerization
A0055085biological_processtransmembrane transport
A0071466biological_processcellular response to xenobiotic stimulus
A0071774biological_processresponse to fibroblast growth factor
A0071805biological_processpotassium ion transmembrane transport
A0099505biological_processregulation of presynaptic membrane potential
A0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A1901379biological_processregulation of potassium ion transmembrane transport
A1901381biological_processpositive regulation of potassium ion transmembrane transport
A1990089biological_processresponse to nerve growth factor
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005251molecular_functiondelayed rectifier potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0008076cellular_componentvoltage-gated potassium channel complex
B0009636biological_processresponse to toxic substance
B0009642biological_processresponse to light intensity
B0009986cellular_componentcell surface
B0010996biological_processresponse to auditory stimulus
B0014075biological_processresponse to amine
B0016020cellular_componentmembrane
B0019894molecular_functionkinesin binding
B0021549biological_processcerebellum development
B0021554biological_processoptic nerve development
B0021759biological_processglobus pallidus development
B0022038biological_processcorpus callosum development
B0022836molecular_functiongated channel activity
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030673cellular_componentaxolemma
B0032589cellular_componentneuron projection membrane
B0032590cellular_componentdendrite membrane
B0032809cellular_componentneuronal cell body membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0034765biological_processregulation of monoatomic ion transmembrane transport
B0034767biological_processpositive regulation of monoatomic ion transmembrane transport
B0035864biological_processresponse to potassium ion
B0042734cellular_componentpresynaptic membrane
B0042995cellular_componentcell projection
B0043025cellular_componentneuronal cell body
B0043679cellular_componentaxon terminus
B0044305cellular_componentcalyx of Held
B0044325molecular_functiontransmembrane transporter binding
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0051260biological_processprotein homooligomerization
B0051262biological_processprotein tetramerization
B0055085biological_processtransmembrane transport
B0071466biological_processcellular response to xenobiotic stimulus
B0071774biological_processresponse to fibroblast growth factor
B0071805biological_processpotassium ion transmembrane transport
B0099505biological_processregulation of presynaptic membrane potential
B0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B1901379biological_processregulation of potassium ion transmembrane transport
B1901381biological_processpositive regulation of potassium ion transmembrane transport
B1990089biological_processresponse to nerve growth factor
C0001508biological_processaction potential
C0005216molecular_functionmonoatomic ion channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005251molecular_functiondelayed rectifier potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0008076cellular_componentvoltage-gated potassium channel complex
C0009636biological_processresponse to toxic substance
C0009642biological_processresponse to light intensity
C0009986cellular_componentcell surface
C0010996biological_processresponse to auditory stimulus
C0014075biological_processresponse to amine
C0016020cellular_componentmembrane
C0019894molecular_functionkinesin binding
C0021549biological_processcerebellum development
C0021554biological_processoptic nerve development
C0021759biological_processglobus pallidus development
C0022038biological_processcorpus callosum development
C0022836molecular_functiongated channel activity
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0030673cellular_componentaxolemma
C0032589cellular_componentneuron projection membrane
C0032590cellular_componentdendrite membrane
C0032809cellular_componentneuronal cell body membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0034765biological_processregulation of monoatomic ion transmembrane transport
C0034767biological_processpositive regulation of monoatomic ion transmembrane transport
C0035864biological_processresponse to potassium ion
C0042734cellular_componentpresynaptic membrane
C0042995cellular_componentcell projection
C0043025cellular_componentneuronal cell body
C0043679cellular_componentaxon terminus
C0044305cellular_componentcalyx of Held
C0044325molecular_functiontransmembrane transporter binding
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0051260biological_processprotein homooligomerization
C0051262biological_processprotein tetramerization
C0055085biological_processtransmembrane transport
C0071466biological_processcellular response to xenobiotic stimulus
C0071774biological_processresponse to fibroblast growth factor
C0071805biological_processpotassium ion transmembrane transport
C0099505biological_processregulation of presynaptic membrane potential
C0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C1901379biological_processregulation of potassium ion transmembrane transport
C1901381biological_processpositive regulation of potassium ion transmembrane transport
C1990089biological_processresponse to nerve growth factor
D0001508biological_processaction potential
D0005216molecular_functionmonoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005251molecular_functiondelayed rectifier potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0008076cellular_componentvoltage-gated potassium channel complex
D0009636biological_processresponse to toxic substance
D0009642biological_processresponse to light intensity
D0009986cellular_componentcell surface
D0010996biological_processresponse to auditory stimulus
D0014075biological_processresponse to amine
D0016020cellular_componentmembrane
D0019894molecular_functionkinesin binding
D0021549biological_processcerebellum development
D0021554biological_processoptic nerve development
D0021759biological_processglobus pallidus development
D0022038biological_processcorpus callosum development
D0022836molecular_functiongated channel activity
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0030673cellular_componentaxolemma
D0032589cellular_componentneuron projection membrane
D0032590cellular_componentdendrite membrane
D0032809cellular_componentneuronal cell body membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0034765biological_processregulation of monoatomic ion transmembrane transport
D0034767biological_processpositive regulation of monoatomic ion transmembrane transport
D0035864biological_processresponse to potassium ion
D0042734cellular_componentpresynaptic membrane
D0042995cellular_componentcell projection
D0043025cellular_componentneuronal cell body
D0043679cellular_componentaxon terminus
D0044305cellular_componentcalyx of Held
D0044325molecular_functiontransmembrane transporter binding
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0051260biological_processprotein homooligomerization
D0051262biological_processprotein tetramerization
D0055085biological_processtransmembrane transport
D0071466biological_processcellular response to xenobiotic stimulus
D0071774biological_processresponse to fibroblast growth factor
D0071805biological_processpotassium ion transmembrane transport
D0099505biological_processregulation of presynaptic membrane potential
D0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D1901379biological_processregulation of potassium ion transmembrane transport
D1901381biological_processpositive regulation of potassium ion transmembrane transport
D1990089biological_processresponse to nerve growth factor
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues72
DetailsTransmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues80
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues72
DetailsTransmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues20
DetailsMotif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35840580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35840580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PHH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35840580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PHH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35840580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PHL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35840580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PHH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35840580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PHH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P25122","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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