8QUD
Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, D, C) | Potassium voltage-gated channel subfamily C member 1 | polymer | 518 | 58850.1 | 4 | UniProt (P48547) Pfam (PF02214) Pfam (PF00520) Pfam (PF07885) | Homo sapiens (human) | |
| 2 | E, L, R, V (A, B, D, C) | (5R)-5-ethyl-3-(6-spiro[2H-1-benzofuran-3,1'-cyclopropane]-4-yloxypyridin-3-yl)imidazolidine-2,4-dione | non-polymer | 365.4 | 4 | Chemie (WY0) | |||
| 3 | F, M, S, W (A, B, D, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | G, N, T, X (A, B, D, C) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) | |||
| 5 | H, O, Q, U (A, B, D, C) | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE | non-polymer | 734.0 | 4 | Chemie (PCF) | |||
| 6 | I, J, K, P, Y... (A, B, C) | POTASSIUM ION | non-polymer | 39.1 | 6 | Chemie (K) | |||
| 7 | AA, BA, CA, DA (A, B, D, C) | water | water | 18.0 | 108 | Chemie (HOH) |
Sequence modifications
A, B, D, C: 1 - 511 (UniProt: P48547)
| PDB | External Database | Details |
|---|---|---|
| His 22 | Tyr 22 | engineered mutation |
| Ala 512 | - | expression tag |
| Glu 513 | - | expression tag |
| Asn 514 | - | expression tag |
| Leu 515 | - | expression tag |
| Tyr 516 | - | expression tag |
| Phe 517 | - | expression tag |
| Gln 518 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 235400.3 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 6840.8 | |
| All* | Total formula weight | 242241.1 |
