3NQJ
| |
5UWW
| |
5V9P
| Crystal structure of pyrrolidine amide inhibitor [(3S)-3-(4-bromo-1H-pyrazol-1-yl)pyrrolidin-1-yl][3-(propan-2-yl)-1H-pyrazol-5-yl]methanone (compound 35) in complex with KDM5A | 分子名称: | Lysine-specific demethylase 5A, NICKEL (II) ION, SULFATE ION, ... | 著者 | Kiefer, J.R, Liang, J, Vinogradova, M. | 登録日 | 2017-03-23 | 公開日 | 2017-05-10 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
|
|
2ZKF
| Crystal structure of the SRA domain of mouse Np95 in complex with hemi-methylated CpG DNA | 分子名称: | DNA (5'-D(*DCP*DTP*DAP*DTP*DCP*(5CM)P*DGP*DGP*DTP*DGP*DA)-3'), DNA (5'-D(P*DCP*DAP*DCP*DCP*DGP*DGP*DAP*DTP*DAP*DGP*DA)-3'), E3 ubiquitin-protein ligase UHRF1 | 著者 | Arita, K, Ariyoshi, M, Tochio, H, Nakamura, Y, Shirakawa, M. | 登録日 | 2008-03-19 | 公開日 | 2008-09-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism Nature, 455, 2008
|
|
2ZO0
| mouse NP95 SRA domain DNA specific complex 1 | 分子名称: | DNA (5'-D(*DGP*DTP*DCP*DAP*DGP*(5CM)P*DGP*DCP*DAP*DAP*DTP*DGP*DG)-3'), DNA (5'-D(*DTP*DCP*DCP*DAP*DTP*DGP*DCP*DGP*DCP*DTP*DGP*DAP*DC)-3'), E3 ubiquitin-protein ligase UHRF1 | 著者 | Hashimoto, H, Horton, J.R, Cheng, X. | 登録日 | 2008-05-05 | 公開日 | 2008-09-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix Nature, 455, 2008
|
|
1ZR3
| Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form B) | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, histone macroH2A1.1 | 著者 | Kustatscher, G, Hothorn, M, Pugieux, C, Scheffzek, K, Ladurner, A.G. | 登録日 | 2005-05-19 | 公開日 | 2006-02-14 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Splicing regulates NAD metabolite binding to histone macroH2A. Nat.Struct.Mol.Biol., 12, 2005
|
|
1UPV
| Crystal structure of the human Liver X receptor beta ligand binding domain in complex with a synthetic agonist | 分子名称: | N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, OXYSTEROLS RECEPTOR LXR-BETA | 著者 | Hoerer, S, Schmid, A, Heckel, A, Budzinski, R.M, Nar, H. | 登録日 | 2003-10-13 | 公開日 | 2004-10-20 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structure of the Human Liver X Receptor Beta Ligand-Binding Domain in Complex with a Synthetic Agonist J.Mol.Biol., 334, 2003
|
|
1H69
| CRYSTAL STRUCTURE OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE CO WITH 2,3,5,6,TETRAMETHYL-P-BENZOQUINONE (DUROQUINONE) AT 2.5 ANGSTROM RESOLUTION | 分子名称: | 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE, FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)H DEHYDROGENASE [QUINONE] 1 | 著者 | Faig, M, Bianchet, M.A, Chen, S, Winski, S, Ross, D, Amzel, L.M. | 登録日 | 2001-06-08 | 公開日 | 2001-09-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Structure-Based Development of Anticancer Drugs: Complexes of Nad(P)H:Quinone Oxidoreductase 1 with Chemotherapeutic Quinones Structure, 9, 2001
|
|
1HD0
| HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D0 (HNRNP D0 RBD1), NMR | 分子名称: | PROTEIN (HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D0) | 著者 | Nagata, T, Kurihara, Y, Matsuda, G, Saeki, J, Kohno, T, Yanagida, Y, Ishikawa, F, Uesugi, S, Katahira, M. | 登録日 | 1999-05-18 | 公開日 | 2000-05-18 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0. J.Mol.Biol., 287, 1999
|
|
2ZVL
| Crystal structure of PCNA in complex with DNA polymerase kappa fragment | 分子名称: | DNA polymerase kappa, Proliferating cell nuclear antigen, SULFATE ION, ... | 著者 | Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M. | 登録日 | 2008-11-11 | 公開日 | 2009-02-10 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen J.Biol.Chem., 284, 2009
|
|
1ZR5
| Crystal structure of the macro-domain of human core histone variant macroH2A1.2 | 分子名称: | H2AFY protein | 著者 | Kustatscher, G, Hothorn, M, Pugieux, C, Scheffzek, K, Ladurner, A.G. | 登録日 | 2005-05-19 | 公開日 | 2005-06-21 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | 主引用文献 | Splicing regulates NAD metabolite binding to histone macroH2A. Nat.Struct.Mol.Biol., 12, 2005
|
|
3P53
| Structure of fascin | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, DODECAETHYLENE GLYCOL, Fascin, ... | 著者 | Jansen, S, Dominguez, R. | 登録日 | 2010-10-07 | 公開日 | 2011-06-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mechanism of actin filament bundling by fascin. J.Biol.Chem., 286, 2011
|
|
1HG5
| CALM-N N-terminal domain of clathrin assembly lymphoid myeloid leukaemia protein, inositol(1,2,3,4,5,6)P6 complex | 分子名称: | CLATHRIN ASSEMBLY PROTEIN SHORT FORM, INOSITOL HEXAKISPHOSPHATE | 著者 | Ford, M.G.J, Evans, P.R, McMahon, H.T. | 登録日 | 2000-12-12 | 公開日 | 2001-02-12 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Simultaneous Binding of Ptdins(4,5)P2 and Clathrin by Ap180 in the Nucleation of Clathrin Lattices on Membranes Science, 291, 2001
|
|
5UKF
| Crystal Structure of the Human Vaccinia-related Kinase 1 Bound to an Oxindole Inhibitor | 分子名称: | 4-{[(Z)-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}benzene-1-sulfonamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Counago, R.M, Wells, C, Zuercher, W, Willson, T.M, Bountra, C, Edwards, A.M, Arruda, P, Gileadi, O, Structural Genomics Consortium (SGC) | 登録日 | 2017-01-22 | 公開日 | 2017-03-29 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Sci Rep, 7, 2017
|
|
1GG5
| CRYSTAL STRUCTURE OF A COMPLEX OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE AND A CHEMOTHERAPEUTIC DRUG (E09) AT 2.5 A RESOLUTION | 分子名称: | 3-HYDROXYMETHYL-5-AZIRIDINYL-1METHYL-2-[1H-INDOLE-4,7-DIONE]-PROPANOL, FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)H DEHYDROGENASE [QUINONE] 1 | 著者 | Faig, M, Bianchet, M.A, Winski, S, Hargreaves, R, Moody, C.J, Hudnott, A.R, Ross, D, Amzel, L.M. | 登録日 | 2000-07-12 | 公開日 | 2001-09-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones. Structure, 9, 2001
|
|
5VBO
| CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH LRRK2-IN-1 | 分子名称: | 1,2-ETHANEDIOL, 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain-containing protein 4, ... | 著者 | ZHU, J.-Y, SCHONBRUNN, E. | 登録日 | 2017-03-30 | 公開日 | 2018-04-04 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 2021
|
|
5UMR
| Crystal structure of N-terminal domain of human FACT complex subunit SSRP1 | 分子名称: | FACT complex subunit SSRP1 | 著者 | Su, D, Hu, Q, Thompson, J.R, Heroux, A, Botuyan, M.V, Mer, G. | 登録日 | 2017-01-29 | 公開日 | 2018-01-31 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | 主引用文献 | Crystal structure of N-terminal domain of human FACT complex subunit SSRP1 To Be Published
|
|
3BQO
| Crystal Structure of TRF1 TRFH domain and TIN2 peptide complex | 分子名称: | TERF1-interacting nuclear factor 2, Telomeric repeat-binding factor 1 | 著者 | Chen, Y, Yang, Y, van Overbeek, M, Donigian, J.R, Baciu, P, de Lange, T, Lei, M. | 登録日 | 2007-12-20 | 公開日 | 2008-02-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science, 319, 2008
|
|
3ODL
| Crystal structure of cyclophilin A in complex with Voclosporin Z-ISA247 | 分子名称: | Cyclophilin A, Voclosporin | 著者 | Kuglstatter, A, Stihle, M, Benz, J, Hennig, M. | 登録日 | 2010-08-11 | 公開日 | 2011-02-16 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin). Acta Crystallogr.,Sect.D, 67, 2011
|
|
3O8V
| Crystal Structure of the Tudor Domains from FXR1 | 分子名称: | Fragile X mental retardation syndrome-related protein 1 | 著者 | Lam, R, Guo, Y.H, Adams-Cioaba, M, Bian, C.B, Mackenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2010-08-03 | 公開日 | 2010-08-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Studies of the Tandem Tudor Domains of Fragile X Mental Retardation Related Proteins FXR1 and FXR2. Plos One, 5, 2010
|
|
5UVF
| Crystal Structure of the Human vaccinia-related kinase bound to BI-D1870 | 分子名称: | (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Counago, R.M, Bountra, C, Arruda, P, Edwards, A.M, Gileadi, O, Structural Genomics Consortium (SGC) | 登録日 | 2017-02-20 | 公開日 | 2017-03-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Sci Rep, 7, 2017
|
|
5UWJ
| |
5UNA
| Fragment of 7SK snRNA methylphosphate capping enzyme | 分子名称: | 7SK snRNA methylphosphate capping enzyme, S-ADENOSYL-L-HOMOCYSTEINE, unidentified peptide section/fragment | 著者 | Wu, H, Tempel, W, Dombrovski, L, McCarthy, A.A, Loppnau, P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2017-01-30 | 公開日 | 2017-03-08 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Fragment of 7SK snRNA methylphosphate capping enzyme To Be Published
|
|
5TI4
| CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR 8841871 | 分子名称: | 1,2-ETHANEDIOL, 3-chloro-4-fluoro-N-[3-(2-oxopyrrolidin-1-yl)phenyl]benzene-1-sulfonamide, Bromodomain-containing protein 4 | 著者 | Zhu, J.-Y, Ember, S.W.J, SCHONBRUNN, E. | 登録日 | 2016-09-30 | 公開日 | 2017-08-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations. ACS Omega, 2, 2017
|
|
5TLE
| |