1GG5

CRYSTAL STRUCTURE OF A COMPLEX OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE AND A CHEMOTHERAPEUTIC DRUG (E09) AT 2.5 A RESOLUTION

Summary for 1GG5

DescriptorNAD(P)H DEHYDROGENASE [QUINONE] 1, FLAVIN-ADENINE DINUCLEOTIDE, 3-HYDROXYMETHYL-5-AZIRIDINYL-1METHYL-2-[1H-INDOLE-4,7-DIONE]-PROPANOL, ... (4 entities in total)
Functional Keywordsflavoprotein, rossmann fold, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P15559
Total number of polymer chains4
Total molecular weight127409.1
Authors
Faig, M.,Bianchet, M.A.,Winski, S.,Hargreaves, R.,Moody, C.J.,Hudnott, A.R.,Ross, D.,Amzel, L.M. (deposition date: 2000-07-12, release date: 2001-09-12, Last modification date: 2014-11-12)
Primary citation
Faig, M.,Bianchet, M.A.,Winski, S.,Hargreaves, R.,Moody, C.J.,Hudnott, A.R.,Ross, D.,Amzel, L.M.
Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones.
Structure, 9:659-667, 2001
PubMed: 11587640 (PDB entries with the same primary citation)
DOI: 10.1016/S0969-2126(01)00636-0
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers190.3%4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution