1GG5
CRYSTAL STRUCTURE OF A COMPLEX OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE AND A CHEMOTHERAPEUTIC DRUG (E09) AT 2.5 A RESOLUTION
Summary for 1GG5
Entry DOI | 10.2210/pdb1gg5/pdb |
Descriptor | NAD(P)H DEHYDROGENASE [QUINONE] 1, FLAVIN-ADENINE DINUCLEOTIDE, 3-HYDROXYMETHYL-5-AZIRIDINYL-1METHYL-2-[1H-INDOLE-4,7-DIONE]-PROPANOL, ... (4 entities in total) |
Functional Keywords | flavoprotein, rossmann fold, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15559 |
Total number of polymer chains | 4 |
Total formula weight | 127409.10 |
Authors | Faig, M.,Bianchet, M.A.,Winski, S.,Hargreaves, R.,Moody, C.J.,Hudnott, A.R.,Ross, D.,Amzel, L.M. (deposition date: 2000-07-12, release date: 2001-09-12, Last modification date: 2023-12-27) |
Primary citation | Faig, M.,Bianchet, M.A.,Winski, S.,Hargreaves, R.,Moody, C.J.,Hudnott, A.R.,Ross, D.,Amzel, L.M. Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones. Structure, 9:659-667, 2001 Cited by PubMed: 11587640DOI: 10.1016/S0969-2126(01)00636-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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