5TLE
Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with the inhibitor 2-phosphate-naphthalene 6-bisphosphonate
Summary for 5TLE
Entry DOI | 10.2210/pdb5tle/pdb |
Related | 5TLH 5TLW 5TLZ |
Descriptor | Fructose-bisphosphate aldolase A, {[6-(phosphonooxy)naphthalen-2-yl]methylene}bis(phosphonic acid), GLYCEROL, ... (4 entities in total) |
Functional Keywords | inhibitor, bisphosphonate, complex, aldolase, lyase, lyase-inhibitor complex, lyase/inhibitor |
Biological source | Oryctolagus cuniculus (Rabbit) |
Total number of polymer chains | 4 |
Total formula weight | 158831.42 |
Authors | Heron, P.W.,Sygusch, J. (deposition date: 2016-10-11, release date: 2017-10-25, Last modification date: 2023-10-18) |
Primary citation | Heron, P.W.,Abellan-Flos, M.,Salmon, L.,Sygusch, J. Bisphosphonate Inhibitors of Mammalian Glycolytic Aldolase. J.Med.Chem., 61:10558-10572, 2018 Cited by PubMed: 30418024DOI: 10.1021/acs.jmedchem.8b01000 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.576 Å) |
Structure validation
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