2ZKF

Crystal structure of the SRA domain of mouse Np95 in complex with hemi-methylated CpG DNA

Summary for 2ZKF

• Entry DOI: 10.2210/pdb2zkf/pdb
• Related: 2ZKD 2ZKE 2ZKG
• Descriptor: E3 ubiquitin-protein ligase UHRF1, DNA (5'-D(P*DCP*DAP*DCP*DCP*DGP*DGP*DAP*DTP*DAP*DGP*DA)-3'), DNA (5'-D(*DCP*DTP*DAP*DTP*DCP*(5CM)P*DGP*DGP*DTP*DGP*DA)-3'), ... (4 entities in total)
• Functional Keywords: protein-dna interaction, cell cycle, developmental protein, dna damage, dna repair, dna-binding, ligase, metal-binding, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation pathway, zinc-finger
• Biological source: Mus musculus (Mouse); More
• Cellular location: Nucleus : Q8VDF2
• Total number of polymer chains: 3
• Total formula weight: 30137.56

Authors

Arita, K.,Ariyoshi, M.,Tochio, H.,Nakamura, Y.,Shirakawa, M. (deposition date: 2008-03-19, release date: 2008-09-09, Last modification date: 2023-11-01)

• Primary citation: Arita, K.,Ariyoshi, M.,Tochio, H.,Nakamura, Y.,Shirakawa, M.; Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism; Nature, 455:818-821, 2008; PubMed: 18772891; DOI: 10.1038/nature07249

Experimental method

X-RAY DIFFRACTION (2.55 Å)