2ZKF
Crystal structure of the SRA domain of mouse Np95 in complex with hemi-methylated CpG DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | E3 ubiquitin-protein ligase UHRF1 | polymer | 210 | 23407.1 | 1 | UniProt (Q8VDF2) Pfam (PF02182) | Mus musculus (Mouse) | Ubiquitin-like PHD and RING finger domain-containing protein 1, Ubiquitin-like-containing PHD and RING finger domains protein 1, Nuclear zinc finger protein Np95, Nuclear protein 95 |
| 2 | B (C) | DNA (5'-D(P*DCP*DAP*DCP*DCP*DGP*DGP*DAP*DTP*DAP*DGP*DA)-3') | polymer | 11 | 3367.2 | 1 | oligonucleotides containing hemi-methylated CpG site | ||
| 3 | C (D) | DNA (5'-D(*DCP*DTP*DAP*DTP*DCP*(5CM)P*DGP*DGP*DTP*DGP*DA)-3') | polymer | 11 | 3363.2 | 1 | oligonucleotides containing hemi-methylated CpG site | ||
| 4 | D, E, F (A, C, D) | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A: 404 - 613 (UniProt: Q8VDF2)
| PDB | External Database | Details |
|---|---|---|
| Ser 404 | Lys 404 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 30137.6 | |
| All* | Total formula weight | 30137.6 |
