PDB: 5578 件ウェブページステータス検索Chemie searchBIRD

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2ZVL	Crystal structure of PCNA in complex with DNA polymerase kappa fragment 分子名称: DNA polymerase kappa, Proliferating cell nuclear antigen, SULFATE ION, ... 著者 Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M. 登録日 2008-11-11 公開日 2009-02-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen J.Biol.Chem., 284, 2009
6O3E	mouse aE-catenin 82-883 分子名称: Catenin alpha-1 著者 Pokutta, S, Weis, W.I. 登録日 2019-02-26 公開日 2019-11-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.001 Å) 主引用文献 Binding partner- and force-promoted changes in alpha E-catenin conformation probed by native cysteine labeling. Sci Rep, 9, 2019
8D3F	Crystal structure of human STAT1 in complex with the repeat region from Toxoplasma protein TgIST 分子名称: Signal transducer and activator of transcription 1-alpha/beta,Inhibitor of STAT1-dependent transcription TgIST 著者 Huang, Z, Liu, H, Nix, J.C, Amarasinghe, G.K, Sibley, L.D. 登録日 2022-06-01 公開日 2022-07-06 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.97 Å) 主引用文献 The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment. Nat Commun, 13, 2022
3A6P	Crystal structure of Exportin-5:RanGTP:pre-miRNA complex 分子名称: 13-mer peptide, Exportin-5, GTP-binding nuclear protein Ran, ... 著者 Okada, C, Yamashita, E, Lee, S.J, Shibata, S, Katahira, J, Nakagawa, A, Yoneda, Y, Tsukihara, T. 登録日 2009-09-07 公開日 2009-12-08 最終更新日 2012-04-25 実験手法 X-RAY DIFFRACTION (2.92 Å) 主引用文献 A high-resolution structure of the pre-microRNA nuclear export machinery Science, 326, 2009
6O5F	Crystal structure of DEAD-box RNA helicase DDX3X at pre-unwound state 分子名称: ATP-dependent RNA helicase DDX3X, CHLORIDE ION, RNA (5'-R(P*CP*AP*AP*GP*GP*UP*CP*AP*UP*UP*CP*GP*CP*AP*AP*GP*AP*GP*UP*GP*GP*CP*C)-3') 著者 Song, H, Ji, X. 登録日 2019-03-02 公開日 2019-07-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.504 Å) 主引用文献 The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X. Nat Commun, 10, 2019
6OI0	Crystal structure of human WDR5 in complex with L-arginine 分子名称: ARGININE, GLYCEROL, SULFATE ION, ... 著者 Lorton, B.M, Harijan, R.K, Burgos, E, Bonanno, J.B, Almo, S.C, Shechter, D. 登録日 2019-04-08 公開日 2020-04-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5. Biochemistry, 59, 2020
5T2W	Structure of thymine DNA glycosylase bound to substrate analog 2'-F-5-formyl-dC 分子名称: DNA (27-MER), DNA (28-MER), G/T mismatch-specific thymine DNA glycosylase 著者 Pidugu, L.S, Pozharski, E, Drohat, A.C. 登録日 2016-08-24 公開日 2016-11-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase. Biochemistry, 55, 2016
6OJV	Crystal structure of human thymidylate synthase delta(7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, N-{4-[(2-amino-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamic acid, Thymidylate synthase,Thymidylate synthase 著者 Czyzyk, D.J, Anderson, K.S, Valhondo, M, Jorgensen, W.L. 登録日 2019-04-12 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.593 Å) 主引用文献 Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase. Febs Lett., 593, 2019
6OJU	Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-D-glutamic acid 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}-D-glutamic acid, Thymidylate synthase,Thymidylate synthase 著者 Czyzyk, D.J, Anderson, K.S, Valhondo, M, Jorgensen, W.L. 登録日 2019-04-12 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.884 Å) 主引用文献 Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase. Febs Lett., 593, 2019
5TLH	Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with the inhibitor 2-naphthol 6-bisphosphonate 分子名称: Fructose-bisphosphate aldolase A, GLYCEROL, METHYLENEDIPHOSPHONIC ACID, ... 著者 Heron, P.W, Sygusch, J. 登録日 2016-10-11 公開日 2017-10-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.204 Å) 主引用文献 Bisphosphonate Inhibitors of Mammalian Glycolytic Aldolase. J.Med.Chem., 61, 2018
5TI3	CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR 17503468 分子名称: 1,2-ETHANEDIOL, 2,5-dibromo-N-[3-(2-oxopyrrolidin-1-yl)phenyl]benzene-1-sulfonamide, Bromodomain-containing protein 4 著者 Zhu, J.-Y, Ember, S.W.J, SCHONBRUNN, E. 登録日 2016-09-30 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.703 Å) 主引用文献 Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations. ACS Omega, 2, 2017
5TD9	Structure of Human Enolase 2 分子名称: CHLORIDE ION, Gamma-enolase, MAGNESIUM ION 著者 Leonard, P.G, Muller, F.L. 登録日 2016-09-19 公開日 2017-09-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.318 Å) 主引用文献 Pomhex, a cell-permeable Enolase inhibitor for Collateral Lethality targeting of ENO1-deleted Glioblastoma To Be Published
8DEY	Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2,3) and the molecular glue DKY709 分子名称: (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ... 著者 Ma, X, Ornelas, E, Clifton, M.C. 登録日 2022-06-21 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Cell Chem Biol, 30, 2023
6OEB	Crystal structure of HMCES SRAP domain in complex with 3' overhang DNA 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*CP*CP*AP*GP*AP*CP*GP*TP*T)-3'), DNA (5'-D(*GP*TP*CP*TP*GP*G)-3'), ... 著者 Halabelian, L, Ravichandran, M, Li, Y, Zeng, H, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) 登録日 2019-03-27 公開日 2019-04-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition. Nat.Struct.Mol.Biol., 26, 2019
5TI6	CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR 8841881 分子名称: 1,2-ETHANEDIOL, 2,6-difluoro-N-[3-(2-oxopyrrolidin-1-yl)phenyl]benzene-1-sulfonamide, Bromodomain-containing protein 4 著者 Zhu, J.-Y, Ember, S.W.J, Schonbrunn, E. 登録日 2016-10-01 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.704 Å) 主引用文献 Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations. ACS Omega, 2, 2017
6O5K	Murine TRIM28 Bbox1 domain 分子名称: Transcription intermediary factor 1-beta, ZINC ION 著者 Sun, Y, Keown, J.R, Goldstone, D.C. 登録日 2019-03-03 公開日 2019-06-19 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family. J.Mol.Biol., 431, 2019
5TI2	CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR 7635936 分子名称: 1,2-ETHANEDIOL, 3-fluoro-N-[3-(2-oxopyrrolidin-1-yl)phenyl]benzene-1-sulfonamide, Bromodomain-containing protein 4 著者 Zhu, J.-Y, Ember, S.W.J, SCHONBRUNN, E. 登録日 2016-09-30 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations. ACS Omega, 2, 2017
5TI7	CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR 17528462 分子名称: 1,2-ETHANEDIOL, 5-bromo-2-methoxy-N-(3-(2-oxopyrrolidin-1-yl)phenyl)benzenesulfonamide, Bromodomain-containing protein 4 著者 Zhu, J.-Y, Ember, S.W.J, Schonbrunn, E. 登録日 2016-10-01 公開日 2017-08-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations. ACS Omega, 2, 2017
6OJQ	Monomeric kinesin-1 motor domain in no-nucleotide state bound to GMPCPP-stabilized microtubule 分子名称: GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, MAGNESIUM ION, ... 著者 Cha, H.K, Debs, G. 登録日 2019-04-12 公開日 2020-04-15 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 Structural Intermediates of the Dimeric Kinesin Stepping Cycle Revealed by Cryo-EM To Be Published
3ACA	Crystal structure of human NUDT5 complexed with 8-oxo-dADP and manganese 分子名称: 8-oxo-7,8-dihydro-2'-deoxy-adenosine-5'-diphosphate, ADP-sugar pyrophosphatase, MANGANESE (II) ION 著者 Arimori, T, Yamagata, Y. 登録日 2009-12-30 公開日 2011-01-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Diverse substrate recognition and hydrolysis mechanisms of human NUDT5 Nucleic Acids Res., 39, 2011
5TI5	CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR 8841880 分子名称: 1,2-ETHANEDIOL, 3-bromo-N-[3-(2-oxo-2,3-dihydro-1H-pyrrol-1-yl)phenyl]benzene-1-sulfonamide, Bromodomain-containing protein 4 著者 Zhu, J.-Y, Ember, S.W.J, Schonbrunn, E. 登録日 2016-10-01 公開日 2017-08-09 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations. ACS Omega, 2, 2017
8CUC	Crystal structure analysis of SALL4 zinc finger domain in complex with DNA 分子名称: DNA (5'-D(P*CP*GP*AP*AP*AP*TP*AP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*TP*AP*TP*TP*TP*CP*G)-3'), Sal-like protein 4, ... 著者 Seo, H.S, Dhe-Paganon, S. 登録日 2022-05-17 公開日 2023-05-24 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Crystal Structure Analysis of SALL4 Zinc Finger domain in complex with DNA To Be Published
8CV5	Peptide 4.2B in complex with BRD3.2 分子名称: ACETYL GROUP, AMINO GROUP, Bromodomain-containing protein 3, ... 著者 Franck, C, Mackay, J.P. 登録日 2022-05-18 公開日 2023-05-24 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins. Structure, 31, 2023
3A1Q	Crystal structure of the mouse RAP80 UIMs in complex with Lys63-linked di-ubiquitin 分子名称: Ubiquitin, Ubiquitin interaction motif-containing protein 1 著者 Sato, Y, Yoshikawa, A, Mimura, H, Yamashita, M, Yamagata, A, Fukai, S. 登録日 2009-04-21 公開日 2009-07-21 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80 Embo J., 28, 2009
6OI1	Crystal structure of human WDR5 in complex with monomethyl L-arginine 分子名称: (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid, GLYCEROL, SULFATE ION, ... 著者 Lorton, B.M, Harijan, R.K, Burgos, E, Bonanno, J.B, Almo, S.C, Shechter, D. 登録日 2019-04-08 公開日 2020-04-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5. Biochemistry, 59, 2020

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