5TLH

Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with the inhibitor 2-naphthol 6-bisphosphonate

Summary for 5TLH

Entry DOI	10.2210/pdb5tlh/pdb
Related	5TLE 5TLW 5TLZ
Descriptor	Fructose-bisphosphate aldolase A, [(6-hydroxynaphthalen-2-yl)methylene]bis(phosphonic acid), METHYLENEDIPHOSPHONIC ACID, ... (5 entities in total)
Functional Keywords	inhibitor, bisphosphonate, complex, aldolase, lyase, lyase-inhibitor complex, lyase/inhibitor
Biological source	Oryctolagus cuniculus (Rabbit)
Total number of polymer chains	4
Total formula weight	159215.51
Authors	Heron, P.W.,Sygusch, J. (deposition date: 2016-10-11, release date: 2017-10-25, Last modification date: 2023-10-18)
Primary citation	Heron, P.W.,Abellan-Flos, M.,Salmon, L.,Sygusch, J. Bisphosphonate Inhibitors of Mammalian Glycolytic Aldolase. J.Med.Chem., 61:10558-10572, 2018 Cited by PubMed: 30418024 DOI: 10.1021/acs.jmedchem.8b01000 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.204 Å)

Structure validation