8D3F

Crystal structure of human STAT1 in complex with the repeat region from Toxoplasma protein TgIST

Summary for 8D3F

Entry DOI	10.2210/pdb8d3f/pdb
Descriptor	Signal transducer and activator of transcription 1-alpha/beta,Inhibitor of STAT1-dependent transcription TgIST (1 entity in total)
Functional Keywords	signal transduction, transcriptional activation, pathogen effector, interferon signaling, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	73359.93
Authors	Huang, Z.,Liu, H.,Nix, J.C.,Amarasinghe, G.K.,Sibley, L.D. (deposition date: 2022-06-01, release date: 2022-07-06, Last modification date: 2023-10-25)
Primary citation	Huang, Z.,Liu, H.,Nix, J.,Xu, R.,Knoverek, C.R.,Bowman, G.R.,Amarasinghe, G.K.,Sibley, L.D. The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment. Nat Commun, 13:4047-4047, 2022 Cited by PubMed: 35831295 DOI: 10.1038/s41467-022-31720-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.97 Å)

Structure validation