8D3F

Crystal structure of human STAT1 in complex with the repeat region from Toxoplasma protein TgIST

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0007165	biological_process	signal transduction

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: N6-methyllysine => ECO:0000269|PubMed:28753426

Chain	Residue	Details
A	LYS175
A	LYS296
A	LYS366
A	LYS525
A	LYS637
A	LYS665

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: ADP-ribosyl glutamic acid; by PARP14 => ECO:0000269|PubMed:27796300

Chain	Residue	Details
A	GLU657
A	GLU705

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by JAK1, JAK2 or TYK2 => ECO:0000269|PubMed:17561467, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:22065572, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:27796300, ECO:0000269|PubMed:28753426, ECO:0000269|PubMed:7657660

Chain	Residue	Details
A	TYR701

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by IKKE => ECO:0000269|PubMed:22065572

Chain	Residue	Details
A	SER708

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS703

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