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6OI1

Crystal structure of human WDR5 in complex with monomethyl L-arginine

Summary for 6OI1
Entry DOI10.2210/pdb6oi1/pdb
DescriptorWD repeat-containing protein 5, SULFATE ION, GLYCEROL, ... (5 entities in total)
Functional Keywordsmethylation, epigenetics, post-translational modification, chromatin, methylarginine, gene regulation
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight34859.47
Authors
Lorton, B.M.,Harijan, R.K.,Burgos, E.,Bonanno, J.B.,Almo, S.C.,Shechter, D. (deposition date: 2019-04-08, release date: 2020-04-01, Last modification date: 2023-10-11)
Primary citationLorton, B.M.,Harijan, R.K.,Burgos, E.S.,Bonanno, J.B.,Almo, S.C.,Shechter, D.
A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5.
Biochemistry, 59:3696-3708, 2020
Cited by
PubMed: 32207970
DOI: 10.1021/acs.biochem.0c00035
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.68 Å)
Structure validation

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