PDB: 98041 件ウェブページステータス検索Chemie searchBIRD

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8P25	Solution structure of a chimeric U2AF2 RRM2 / FUBP1 N-Box 分子名称: Splicing factor U2AF 65 kDa subunit,Far upstream element-binding protein 1 著者 Hipp, C, Sattler, M. 登録日 2023-05-14 公開日 2023-07-26 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 FUBP1 is a general splicing factor facilitating 3' splice site recognition and splicing of long introns. Mol.Cell, 83, 2023
6RZX	Carbonic Anhydrase CAIX mimic in complex with inhibitor FBSA 分子名称: 1,1,2,2,3,3,4,4,4-nonakis(fluoranyl)butane-1-sulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Kugler, M, Brynda, J, Rezacova, P. 登録日 2019-06-13 公開日 2020-06-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA). SLAS Discov, 25, 2020
8GCR	HPV16 E6-E6AP-p53 complex 分子名称: Cellular tumor antigen p53, Maltose/maltodextrin-binding periplasmic protein,Protein E6, Ubiquitin-protein ligase E3A, ... 著者 Bratkowski, M.A, Wang, J.C.K, Hao, Q, Nile, A.H. 登録日 2023-03-02 公開日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.38 Å) 主引用文献 Structure of the p53 degradation complex from HPV16. Nat Commun, 15, 2024
4TMR	Crystal structure of ternary complex of Plasmodium vivax SHMT with glycine and a novel pyrazolopyran 99S: methyl 5-{3-[(4S)-6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl}thiophene-2-carboxylate . 分子名称: CHLORIDE ION, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], Serine hydroxymethyltransferase, ... 著者 Chitnumsub, P, Jaruwat, A, Leartsakulpanich, U, Witschel, M.C. 登録日 2014-06-02 公開日 2015-03-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities. J.Med.Chem., 58, 2015
4TQN	Crystal structure of the bromodomain of human CREBBP in complex with UL04 分子名称: 1,2-ETHANEDIOL, 3-[(5-acetyl-2-ethoxyphenyl)carbamoyl]benzoic acid, CREB-binding protein 著者 Dong, J, Caflisch, A. 登録日 2014-06-11 公開日 2015-06-24 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery of CREBBP Bromodomain Inhibitors by High-Throughput Docking and Hit Optimization Guided by Molecular Dynamics. J.Med.Chem., 59, 2016
6LXD	Pri-miRNA bound DROSHA-DGCR8 complex 分子名称: Microprocessor complex subunit DGCR8, RNA (102-mer), Ribonuclease 3, ... 著者 Jin, W, Wang, J, Liu, C.P, Wang, H.W, Xu, R.M. 登録日 2020-02-10 公開日 2020-04-15 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural Basis for pri-miRNA Recognition by Drosha. Mol.Cell, 78, 2020
4RKJ	Crystal structure of thrombin mutant S195T (free form) 分子名称: GLYCEROL, POTASSIUM ION, Thrombin heavy chain, ... 著者 Pelc, A.L, Chen, Z, Gohara, D.W, Vogt, A.D, Pozzi, N, Di Cera, E. 登録日 2014-10-13 公開日 2015-03-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Why ser and not thr brokers catalysis in the trypsin fold. Biochemistry, 54, 2015
8HR6	leucine DEHYDROGENASE STRUCTURE IN TERNARY COMPLEX WITH NAD+ from Bacillus thuringiensis 分子名称: Leucine dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION 著者 Li, X, Song, W. 登録日 2022-12-14 公開日 2024-03-20 実験手法 X-RAY DIFFRACTION (3.52 Å) 主引用文献 A Tri-Enzyme Cascade for Efficient Production of L-2-Aminobutyrate from L-Threonine. Chembiochem, 24, 2023
4F3F	Crystal Structure of Msln7-64 MORAb-009 FAB complex 分子名称: MORAb-009 Fab heavy chain, MORAb-009 Fab light chain, Mesothelin 著者 Xia, D, Pastan, I, Ma, J, Tang, W.K, Esser, L. 登録日 2012-05-09 公開日 2012-07-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights. J.Biol.Chem., 287, 2012
5ORL	Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment 分子名称: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, CHLORIDE ION, ... 著者 McIntyre, P.J, Collins, P.M, Vrzal, L, Birchall, K, Arnold, L.H, Mpamhanga, C, Coombs, P.J, Burgess, S.G, Richards, M.W, Winter, A, Veverka, V, von Delft, F, Merritt, A, Bayliss, R. 登録日 2017-08-16 公開日 2017-11-01 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches. ACS Chem. Biol., 12, 2017
1VJI	Gene Product of At1g76680 from Arabidopsis thaliana 分子名称: 12-oxophytodienoate reductase (OPR1), FLAVIN MONONUCLEOTIDE 著者 Wesenberg, G.E, Smith, D.W, Phillips Jr, G.N, Johnson, K.A, Bingman, C.A, Center for Eukaryotic Structural Genomics (CESG) 登録日 2004-02-24 公開日 2004-03-16 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.003 Å) 主引用文献 X-ray structure of Arabidopsis At1g77680, 12-oxophytodienoate reductase isoform 1. Proteins, 61, 2005
4RLF	Crystal structure of a benzoate coenzyme A ligase with p-Toluic acid and o-Toluic acid 分子名称: 2-methylbenzoic acid, 4-METHYLBENZOIC ACID, Benzoate-coenzyme A ligase, ... 著者 Strom, S, Nosrati, M, Thornburg, C, Walker, K, Geiger, J.H. 登録日 2014-10-16 公開日 2015-09-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Kinetically and Crystallographically Guided Mutations of a Benzoate CoA Ligase (BadA) Elucidate Mechanism and Expand Substrate Permissivity. Biochemistry, 54, 2015
4RM3	Crystal structure of a benzoate coenzyme A ligase with 2-Furoic acid 分子名称: 2-FUROIC ACID, Benzoate-coenzyme A ligase 著者 Strom, S, Nosrati, M, Thornburg, C, Walker, K.D, Geiger, J.H. 登録日 2014-10-18 公開日 2015-09-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Kinetically and Crystallographically Guided Mutations of a Benzoate CoA Ligase (BadA) Elucidate Mechanism and Expand Substrate Permissivity. Biochemistry, 54, 2015
4RMK	Crystal structure of the Olfactomedin domain of latrophilin 3 in P65 crystal form 分子名称: CALCIUM ION, Latrophilin-3 著者 Ranaivoson, F.M, Liu, Q, Martini, F, Bergami, F, Von daake, S, Li, S, Demeler, B, Hendrickson, W.A, Comoletti, D. 登録日 2014-10-21 公開日 2015-08-19 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (1.606 Å) 主引用文献 Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development. Structure, 23, 2015
4RMR	Crystal structure of the D38N Beta-2 Microglobulin mutant 分子名称: ACETATE ION, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER 著者 de Rosa, M, Bolognesi, M, Ricagno, S. 登録日 2014-10-22 公開日 2015-11-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.529 Å) 主引用文献 Decoding the Structural Bases of D76N 2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis. Plos One, 10, 2015
2F21	human Pin1 Fip mutant 分子名称: PENTAETHYLENE GLYCOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 著者 Jager, M, Zhang, Y, Bowman, M.E, Noel, J.P, Kelly, J.W. 登録日 2005-11-15 公開日 2006-06-20 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-function-folding relationship in a WW domain. Proc.Natl.Acad.Sci.Usa, 103, 2006
4HAW	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K548A)-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... 著者 Sun, Q, Chook, Y.M. 登録日 2012-09-27 公開日 2013-01-09 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4S1Q	Crystal structure of a VRC01-lineage antibody, 45-VRC01.H03+06.D-001739, in complex with clade A/E HIV-1 gp120 core 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab of VRC01 light chain, Fab of VRC01-lineage antibody,45-VRC01.H03+06.D-001739 heavy chain, ... 著者 Kwon, Y.D, Yang, Y, Zhang, B, Kwong, P.D. 登録日 2015-01-14 公開日 2015-04-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection. Cell(Cambridge,Mass.), 161, 2015
102L	HOW AMINO-ACID INSERTIONS ARE ALLOWED IN AN ALPHA-HELIX OF T4 LYSOZYME 分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME 著者 Heinz, D.W, Matthews, B.W. 登録日 1992-09-29 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 How amino-acid insertions are allowed in an alpha-helix of T4 lysozyme. Nature, 361, 1993
4RMQ	Crystal structure of the D59N Beta-2 Microglobulin mutant 分子名称: Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER 著者 de Rosa, M, Bolognesi, M, Ricagno, S. 登録日 2014-10-22 公開日 2015-11-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.461 Å) 主引用文献 Decoding the Structural Bases of D76N 2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis. Plos One, 10, 2015
4HAT	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... 著者 Sun, Q, Chook, Y.M. 登録日 2012-09-27 公開日 2013-01-09 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4RM2	Crystal structure of a benzoate coenzyme A ligase with 2-Fluoro benzoic acid 分子名称: 2-fluorobenzoic acid, Benzoate-coenzyme A ligase 著者 Strom, S, Nosrati, M, Thornburg, C, Walker, K.D, Geiger, J.H. 登録日 2014-10-18 公開日 2015-09-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Kinetically and Crystallographically Guided Mutations of a Benzoate CoA Ligase (BadA) Elucidate Mechanism and Expand Substrate Permissivity. Biochemistry, 54, 2015
3ZG3	STEROL 14-ALPHA DEMETHYLASE (CYP51)FROM TRYPANOSOMA CRUZI IN COMPLEX WITH THE PYRIDINE INHIBITOR N-(1-(5-(trifluoromethyl)(pyridin-2-yl)) piperidin-4yl)-N-(4-(trifluoromethyl)phenyl)pyridin-3-amine (EPL- BS967, UDD) 分子名称: N-[4-(trifluoromethyl)phenyl]-N-[1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]pyridin-3-amine, PROTOPORPHYRIN IX CONTAINING FE, STEROL 14-ALPHA DEMETHYLASE 著者 Hargrove, T.Y, Wawrzak, Z, Keenan, M, Chatelain, E, Lepesheva, G.I. 登録日 2012-12-14 公開日 2013-09-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Complexes of Trypanosoma Cruzi Sterol 14Alpha-Demethylase (Cyp51) with Two Pyridine-Based Drug Candidates for Chagas Disease: Structural Basis for Pathogen-Selectivity J.Biol.Chem., 288, 2013
5E9Y	Crystal Structure of BAZ2B bromodomain in complex with MPD 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Bromodomain adjacent to zinc finger domain protein 2B 著者 Lolli, G, Caflisch, A. 登録日 2015-10-15 公開日 2016-03-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 High-Throughput Fragment Docking into the BAZ2B Bromodomain: Efficient in Silico Screening for X-Ray Crystallography. Acs Chem.Biol., 11, 2016
6LXE	DROSHA-DGCR8 complex 分子名称: Microprocessor complex subunit DGCR8, Ribonuclease 3, ZINC ION 著者 Jin, W, Wang, J, Liu, C.P, Wang, H.W, Xu, R.M. 登録日 2020-02-10 公開日 2020-04-15 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural Basis for pri-miRNA Recognition by Drosha. Mol.Cell, 78, 2020

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