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3ZG3

STEROL 14-ALPHA DEMETHYLASE (CYP51)FROM TRYPANOSOMA CRUZI IN COMPLEX WITH THE PYRIDINE INHIBITOR N-(1-(5-(trifluoromethyl)(pyridin-2-yl)) piperidin-4yl)-N-(4-(trifluoromethyl)phenyl)pyridin-3-amine (EPL- BS967, UDD)

Summary for 3ZG3
Entry DOI10.2210/pdb3zg3/pdb
Related3ZG2
DescriptorSTEROL 14-ALPHA DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, N-[4-(trifluoromethyl)phenyl]-N-[1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]pyridin-3-amine, ... (4 entities in total)
Functional Keywordsoxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum membrane, inhibitor
Biological sourceTRYPANOSOMA CRUZI
Total number of polymer chains1
Total formula weight53635.81
Authors
Hargrove, T.Y.,Wawrzak, Z.,Keenan, M.,Chatelain, E.,Lepesheva, G.I. (deposition date: 2012-12-14, release date: 2013-09-25, Last modification date: 2023-12-20)
Primary citationHargrove, T.Y.,Wawrzak, Z.,Alexander, P.W.,Chaplin, J.H.,Keenan, M.,Charman, S.A.,Perez, C.J.,Waterman, M.R.,Chatelain, E.,Lepesheva, G.I.
Complexes of Trypanosoma Cruzi Sterol 14Alpha-Demethylase (Cyp51) with Two Pyridine-Based Drug Candidates for Chagas Disease: Structural Basis for Pathogen-Selectivity
J.Biol.Chem., 288:31602-, 2013
Cited by
PubMed: 24047900
DOI: 10.1074/JBC.M113.497990
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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