3ZG2
Sterol 14 alpha-demethylase (CYP51) from Trypanosoma cruzi in complex with the pyridine inhibitor (S)-2-(4-chlorophenyl)-2-(pyridin-3-yl)-1- (4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone (EPL-BS1246,UDO)
Summary for 3ZG2
Entry DOI | 10.2210/pdb3zg2/pdb |
Related | 3ZG3 |
Descriptor | STEROL 14-ALPHA DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, (S)-2-(4-chlorophenyl)-2-pyridin-3-yl-1-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethanone, ... (4 entities in total) |
Functional Keywords | oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum membrane, inhibitor |
Biological source | TRYPANOSOMA CRUZI |
Total number of polymer chains | 1 |
Total formula weight | 53629.28 |
Authors | Hargrove, T.Y.,Wawrzak, Z.,Keenan, M.,Chatelain, E.,Lepesheva, G.I. (deposition date: 2012-12-14, release date: 2013-09-25, Last modification date: 2023-12-20) |
Primary citation | Hargrove, T.Y.,Wawrzak, Z.,Alexander, P.W.,Chaplin, J.H.,Keenan, M.,Charman, S.A.,Perez, C.J.,Waterman, M.R.,Chatelain, E.,Lepesheva, G.I. Complexes of Trypanosoma Cruzi Sterol 14Alpha-Demethylase (Cyp51) with Two Pyridine-Based Drug Candidates for Chagas Disease: Structural Basis for Pathogen-Selectivity J.Biol.Chem., 288:31602-, 2013 Cited by PubMed: 24047900DOI: 10.1074/JBC.M113.497990 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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