4S1Q

Crystal structure of a VRC01-lineage antibody, 45-VRC01.H03+06.D-001739, in complex with clade A/E HIV-1 gp120 core

Summary for 4S1Q

• Entry DOI: 10.2210/pdb4s1q/pdb
• Related: 4S1R 4S1S
• Descriptor: HIV-1 gp120 core, Fab of VRC01-lineage antibody,45-VRC01.H03+06.D-001739 heavy chain, Fab of VRC01 light chain, ... (5 entities in total)
• Functional Keywords: hiv-1, neutralizing antibodies, vrc01-lineage, antibody maturation, evolutionary rate, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1 (HIV-1); More
• Total number of polymer chains: 3
• Total formula weight: 89998.87

Authors

Kwon, Y.D.,Yang, Y.,Zhang, B.,Kwong, P.D. (deposition date: 2015-01-14, release date: 2015-04-22, Last modification date: 2023-09-20)

• Primary citation: Wu, X.,Zhang, Z.,Schramm, C.A.,Joyce, M.G.,Do Kwon, Y.,Zhou, T.,Sheng, Z.,Zhang, B.,O'Dell, S.,McKee, K.,Georgiev, I.S.,Chuang, G.Y.,Longo, N.S.,Lynch, R.M.,Saunders, K.O.,Soto, C.,Srivatsan, S.,Yang, Y.,Bailer, R.T.,Louder, M.K.,Mullikin, J.C.,Connors, M.,Kwong, P.D.,Mascola, J.R.,Shapiro, L.; Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.; Cell(Cambridge,Mass.), 161:470-485, 2015; PubMed: 25865483; DOI: 10.1016/j.cell.2015.03.004

Experimental method

X-RAY DIFFRACTION (2.4 Å)