Crystal structure of a VRC01-lineage antibody, 45-VRC01.H03+06.D-001739, in complex with clade A/E HIV-1 gp120 core

Summary for 4S1Q
Related4S1R 4S1S
DescriptorHIV-1 gp120 core, Fab of VRC01-lineage antibody,45-VRC01.H03+06.D-001739 heavy chain, Fab of VRC01 light chain, ... (5 entities in total)
Functional Keywordshiv-1, neutralizing antibodies, vrc01-lineage, antibody maturation, evolutionary rate, viral protein-immune system complex, viral protein/immune system
Biological sourceHuman immunodeficiency virus 1 (HIV-1)
Total number of polymer chains3
Total formula weight89998.87
Kwon, Y.D.,Yang, Y.,Zhang, B.,Kwong, P.D. (deposition date: 2015-01-14, release date: 2015-04-22, Last modification date: 2021-06-02)
Primary citationBailer, R.T.,Chuang, G.Y.,Connors, M.,Do Kwon, Y.,Georgiev, I.S.,Joyce, M.G.,Kwong, P.D.,Longo, N.S.,Louder, M.K.,Lynch, R.M.,Mascola, J.R.,McKee, K.,Mullikin, J.C.,O'Dell, S.,Saunders, K.O.,Schramm, C.A.,Shapiro, L.,Sheng, Z.,Soto, C.,Srivatsan, S.,Wu, X.,Yang, Y.,Zhang, B.,Zhang, Z.,Zhou, T.
Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.
Cell(Cambridge,Mass.), 161:470-485, 2015
PubMed: 25865483
DOI: 110.1016/j.cell.2015.03.004
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-16