Crystal structure of a VRC01-lineage antibody, 45-VRC01.H08.F-117225, in complex with clade A/E HIV-1 gp120 core

Summary for 4S1R

Related4S1Q 4S1S
Descriptorclade A/E 93TH057 HIV-1 gp120 core, Fab of VRC01-lineage antibody,45-VRC01.H08.F-117225 heavy chain, Fab of VRC01 light chain, ... (4 entities in total)
Functional Keywordshiv-1, neutralizing antibodies, vrc01-lineage, antibody maturation, evolutionary rate, viral protein-immune system-inhibitor complex, viral protein/immune system/inhibitor
Biological sourceHuman immunodeficiency virus 1 (HIV-1)
Total number of polymer chains3
Total molecular weight89851.62
Kwon, Y.D.,Yang, Y.,Zhang, B.,Kwong, P.D. (deposition date: 2015-01-14, release date: 2015-04-22, Last modification date: 2015-05-06)
Primary citation
Wu, X.,Zhang, Z.,Schramm, C.A.,Joyce, M.G.,Do Kwon, Y.,Zhou, T.,Sheng, Z.,Zhang, B.,O'Dell, S.,McKee, K.,Georgiev, I.S.,Chuang, G.Y.,Longo, N.S.,Lynch, R.M.,Saunders, K.O.,Soto, C.,Srivatsan, S.,Yang, Y.,Bailer, R.T.,Louder, M.K.,Mullikin, J.C.,Connors, M.,Kwong, P.D.,Mascola, J.R.,Shapiro, L.
Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.
Cell(Cambridge,Mass.), 161:470-485, 2015
PubMed: 25865483 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2015.03.004
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.286110.9%0.3%5.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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