6RZX

Carbonic Anhydrase CAIX mimic in complex with inhibitor FBSA

Summary for 6RZX

Entry DOI	10.2210/pdb6rzx/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 1,1,2,2,3,3,4,4,4-nonakis(fluoranyl)butane-1-sulfonamide, ... (4 entities in total)
Functional Keywords	carbonic anhydrase, inhibitor, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29551.38
Authors	Kugler, M.,Brynda, J.,Rezacova, P. (deposition date: 2019-06-13, release date: 2020-06-03, Last modification date: 2024-01-24)
Primary citation	Tykvart, J.,Navratil, V.,Kugler, M.,Sacha, P.,Schimer, J.,Hlavackova, A.,Tenora, L.,Zemanova, J.,Dejmek, M.,Kral, V.,Potacek, M.,Majer, P.,Jahn, U.,Brynda, J.,Rezacova, P.,Konvalinka, J. Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA). SLAS Discov, 25:1026-1037, 2020 Cited by PubMed: 32452709 DOI: 10.1177/2472555220918836 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1 Å)

Structure validation