7M2W
| Engineered disulfide cross-linked closed conformation of the Yeast gamma-TuRC(SS) | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Spindle pole body component 110, Spindle pole body component SPC97, ... | 著者 | Brilot, A.F, Lyon, A.S, Zelter, A, Viswanath, S, Maxwell, A, MacCoss, M.J, Muller, E.G, Sali, A, Davis, T.N, Agard, D.A. | 登録日 | 2021-03-17 | 公開日 | 2021-05-12 | 最終更新日 | 2021-05-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | CM1-driven assembly and activation of yeast gamma-tubulin small complex underlies microtubule nucleation. Elife, 10, 2021
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6CT8
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7M2X
| Open conformation of the Yeast wild-type gamma-TuRC | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Spindle pole body component 110, Spindle pole body component SPC97, ... | 著者 | Brilot, A.F, Lyon, A.S, Zelter, A, Viswanath, S, Maxwell, A, MacCoss, M.J, Muller, E.G, Sali, A, Davis, T.N, Agard, D.A. | 登録日 | 2021-03-17 | 公開日 | 2021-05-12 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | CM1-driven assembly and activation of yeast gamma-tubulin small complex underlies microtubule nucleation. Elife, 10, 2021
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7MJM
| Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | 著者 | Zhu, X, Mannar, D, Srivastava, S.S, Berezuk, A.M, Demers, J.P, Saville, J.W, Leopold, K, Li, W, Dimitrov, D.S, Tuttle, K.S, Zhou, S, Chittori, S, Subramaniam, S. | 登録日 | 2021-04-20 | 公開日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies. Plos Biol., 19, 2021
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6W4Q
| Crystal structure of full-length tailspike protein 2 (TSP2, ORF211) ) from Escherichia coli O157:H7 bacteriophage CAB120 | 分子名称: | 1,2-ETHANEDIOL, CARBONATE ION, CHLORIDE ION, ... | 著者 | Greenfield, J, Herzberg, O. | 登録日 | 2020-03-11 | 公開日 | 2021-01-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure and function of bacteriophage CBA120 ORF211 (TSP2), the determinant of phage specificity towards E. coli O157:H7. Sci Rep, 10, 2020
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8A9K
| Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 with ML323 (consensus reconstruction) | 分子名称: | 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, DNA (61-MER), Fanconi anemia group D2 protein, ... | 著者 | Rennie, M.L, Walden, H. | 登録日 | 2022-06-28 | 公開日 | 2022-10-12 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Sci Adv, 8, 2022
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5JJM
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1ZGL
| Crystal structure of 3A6 TCR bound to MBP/HLA-DR2a | 分子名称: | HLA class II histocompatibility antigen, DR alpha chain, Myelin basic protein, ... | 著者 | Li, Y, Huang, Y, Lue, J, Quandt, J.A, Martin, R, Mariuzza, R.A. | 登録日 | 2005-04-21 | 公開日 | 2005-10-18 | 最終更新日 | 2020-02-19 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. Embo J., 24, 2005
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1HD0
| HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D0 (HNRNP D0 RBD1), NMR | 分子名称: | PROTEIN (HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D0) | 著者 | Nagata, T, Kurihara, Y, Matsuda, G, Saeki, J, Kohno, T, Yanagida, Y, Ishikawa, F, Uesugi, S, Katahira, M. | 登録日 | 1999-05-18 | 公開日 | 2000-05-18 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0. J.Mol.Biol., 287, 1999
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6T69
| Crystal structure of Toxoplasma gondii Morn1(V shape) | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Membrane occupation and recognition nexus protein MORN1, ... | 著者 | Grishkovskaya, I, Kostan, J, Sajko, S, Morriswood, B, Djinovic-Carugo, K. | 登録日 | 2019-10-18 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats. Plos One, 15, 2020
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6KNH
| Crystal structure of SbnH in complex with citrate, a PLP-dependent decarboxylase in Staphyloferrin B biothesynthesis | 分子名称: | CITRIC ACID, PHOSPHATE ION, Probable diaminopimelate decarboxylase protein | 著者 | Tang, J, Ju, Y, Zhou, H. | 登録日 | 2019-08-05 | 公開日 | 2019-11-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structural Insights into Substrate Recognition and Activity Regulation of the Key Decarboxylase SbnH in Staphyloferrin B Biosynthesis. J.Mol.Biol., 431, 2019
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6WPI
| Crystal structure of Nop9 in complex with ITS1 RNA | 分子名称: | 3,3',3''-phosphanetriyltripropanoic acid, GLYCEROL, Nucleolar protein 9, ... | 著者 | Zhang, J, Qiu, C, Hall, T.M.T. | 登録日 | 2020-04-27 | 公開日 | 2020-05-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | 主引用文献 | Nop9 recognizes structured and single-stranded RNA elements of preribosomal RNA. Rna, 26, 2020
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5L1H
| AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor GYKI53655 | 分子名称: | (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2 | 著者 | Yelshanskaya, M.V, Singh, A.K, Sampson, J.M, Sobolevsky, A.I. | 登録日 | 2016-07-29 | 公開日 | 2016-10-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.801 Å) | 主引用文献 | Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs. Neuron, 91, 2016
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5MLZ
| Dolichyl phosphate mannose synthase in complex with GDP and Mg2+ | 分子名称: | CHLORIDE ION, Dolichol monophosphate mannose synthase, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Gandini, R, Reichenbach, T, Tan, T.C, Divne, C. | 登録日 | 2016-12-08 | 公開日 | 2017-08-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for dolichylphosphate mannose biosynthesis. Nat Commun, 8, 2017
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6NF4
| Structure of zebrafish Otop1 in nanodiscs | 分子名称: | CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, Otopetrin1 | 著者 | Saotome, K, Lee, W.H, Liman, E.R, Ward, A.B. | 登録日 | 2018-12-18 | 公開日 | 2019-06-05 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structures of the otopetrin proton channels Otop1 and Otop3. Nat.Struct.Mol.Biol., 26, 2019
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6BVA
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7M18
| HeLa-tubulin in complex with cryptophycin 1 | 分子名称: | Cryptophycin 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Eren, E. | 登録日 | 2021-03-12 | 公開日 | 2021-09-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action. J.Biol.Chem., 297, 2021
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7M20
| 18-mer HeLa-tubulin rings in complex with Cryptophycin 1 | 分子名称: | Cryptophycin 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Eren, E. | 登録日 | 2021-03-15 | 公開日 | 2021-09-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | 主引用文献 | Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action. J.Biol.Chem., 297, 2021
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5MJG
| Single-shot pink beam serial crystallography: Thaumatin | 分子名称: | S,R MESO-TARTARIC ACID, SODIUM ION, Thaumatin-1 | 著者 | Meents, A, Oberthuer, D, Lieske, J, Srajer, V. | 登録日 | 2016-12-01 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Single-shot pink beam serial crystallography: Thaumatin To Be Published
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7LXB
| HeLa-tubulin in complex with cryptophycin 52 | 分子名称: | Cryptophycin 52, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Eren, E. | 登録日 | 2021-03-03 | 公開日 | 2021-09-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action. J.Biol.Chem., 297, 2021
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5L1B
| AMPA subtype ionotropic glutamate receptor GluA2 in Apo state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2,Glutamate receptor 2 | 著者 | Yelshanskaya, M.V, Singh, A.K, Sampson, J.M, Sobolevsky, A.I. | 登録日 | 2016-07-28 | 公開日 | 2016-10-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs. Neuron, 91, 2016
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6WQ3
| Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 in Complex with 7-methyl-GpppA and S-adenosyl-L-homocysteine. | 分子名称: | 2'-O-methyltransferase, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Non-structural protein 10, ... | 著者 | Minasov, G, Shuvalova, L, Rosas-Lemus, M, Brunzelle, J.S, Kiryukhina, O, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-04-28 | 公開日 | 2020-05-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | High-resolution structures of the SARS-CoV-2 2'- O -methyltransferase reveal strategies for structure-based inhibitor design. Sci.Signal., 13, 2020
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6NOV
| A Fab derived from ixekizumab | 分子名称: | DODECAETHYLENE GLYCOL, Fab Heavy Chain, Fab Light Chain | 著者 | Durbin, J.D, Clawson, D.K, Lu, F, Tian, Y, Lu, J, Schmitt, M, Atwell, S. | 登録日 | 2019-01-16 | 公開日 | 2019-06-19 | 最終更新日 | 2019-08-14 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Development of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease. Mabs, 11, 2019
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7LUS
| IgG2 Fc Charge Pair Mutation version 1 (CPMv1) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin heavy constant gamma 2 | 著者 | Sudom, A, Whittington, D, Garces, F, Wang, Z. | 登録日 | 2021-02-23 | 公開日 | 2021-09-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Next generation Fc scaffold for multispecific antibodies. Iscience, 24, 2021
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8FBV
| Compound 7 bound to procaspase-6 | 分子名称: | 5-fluoro-2-({[(3M)-3-(1H-imidazol-2-yl)pyridin-2-yl]amino}methyl)phenol, Procaspase-6 | 著者 | Fan, P, Zhao, Y, Renslo, A.R, Arkin, M.R. | 登録日 | 2022-11-30 | 公開日 | 2023-12-13 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Systematic Study of Heteroarene Stacking Using a Congeneric Set of Molecular Glues for Procaspase-6. J.Med.Chem., 66, 2023
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