5L1H

AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor GYKI53655

Summary for 5L1H

• Entry DOI: 10.2210/pdb5l1h/pdb
• Related: 5L1B 5L1E 5L1F 5L1G
• Descriptor: Glutamate receptor 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide (3 entities in total)
• Functional Keywords: transporter, membrane protein, transport protein, transport protein-inhibitor complex, transport protein/inhibitor
• Biological source: Rattus norvegicus (Rat)
• Total number of polymer chains: 4
• Total formula weight: 361517.32

Authors

Yelshanskaya, M.V.,Singh, A.K.,Sampson, J.M.,Sobolevsky, A.I. (deposition date: 2016-07-29, release date: 2016-10-19, Last modification date: 2023-10-04)

• Primary citation: Yelshanskaya, M.V.,Singh, A.K.,Sampson, J.M.,Narangoda, C.,Kurnikova, M.,Sobolevsky, A.I.; Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs.; Neuron, 91:1305-1315, 2016; PubMed: 27618672; DOI: 10.1016/j.neuron.2016.08.012

Experimental method

X-RAY DIFFRACTION (3.801 Å)