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8T2D
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Ubiquitin variant i53:Mutant T12Y.T14E.L67R with 53BP1 Tudor domain
分子名称: Tumor protein p53 binding protein 1, Ubiquitin variant i53
著者Partridge, J.R, Holden, J.K, Wibowo, A.S, Mulichak, A.
登録日2023-06-05
公開日2024-03-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.751 Å)
主引用文献Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair.
Nat Commun, 15, 2024
7CBK
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BU of 7cbk by Molmil
Structure of Human Neutrophil Elastase Ecotin complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ecotin, ...
著者Jobichen, C, Sivaraman, J.
登録日2020-06-12
公開日2020-08-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Basis for the Inhibition Mechanism of Ecotin against Neutrophil Elastase by Targeting the Active Site and Secondary Binding Site.
Biochemistry, 59, 2020
6C98
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Crystal structure of FcRn bound to UCB-84
分子名称: 1-[7-(3-fluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]ethan-1-one, Beta-2-microglobulin, CYSTEINE, ...
著者Fox III, D, Lukacs, C.M.
登録日2018-01-25
公開日2018-05-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.
PLoS Biol., 16, 2018
8BJH
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BU of 8bjh by Molmil
chimera of the inactive ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, with the double mutation K3528M and K3535I, fused to a proline-Rich-Domain (PRD) and profilin, bound to Latrunculin B-ADP-Mg-actin
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Actin, ...
著者Teixeira-Nunes, M, Renault, L, Retailleau, P.
登録日2022-11-04
公開日2023-09-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin.
Plos Pathog., 19, 2023
1GNA
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BU of 1gna by Molmil
DETERMINATION OF THE SOLUTION STRUCTURE OF THE PEPTIDE HORMONE GUANYLIN: OBSERVATION OF A NOVEL FORM OF TOPOLOGICAL STEREOISOMERISM
分子名称: GUANYLIN PRECURSOR
著者Skelton, N.J, Garcia, K.C.
登録日1994-06-30
公開日1994-09-30
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Determination of the solution structure of the peptide hormone guanylin: observation of a novel form of topological stereoisomerism.
Biochemistry, 33, 1994
8BO1
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BU of 8bo1 by Molmil
ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, bound to Latrunculin-B-ATP-Mg-actin, and 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE and 2 Mg ions
分子名称: 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, AZIDE ION, ...
著者Teixeira-Nunes, M, Renault, L, Retailleau, P.
登録日2022-11-14
公開日2023-09-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin.
Plos Pathog., 19, 2023
6N7E
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BU of 6n7e by Molmil
Crystal structure of the cytosolic domain of human CNNM2 in complex with AMP-PNP and Mg2+
分子名称: MAGNESIUM ION, Metal transporter CNNM2,Metal transporter CNNM2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Chen, Y.S, Gehring, K.
登録日2018-11-27
公開日2019-12-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Mg2+-ATP Sensing in CNNM, a Putative Magnesium Transporter.
Structure, 28, 2020
8BJI
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chimera of ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo fused to a proline-Rich-Domain (PRD) and profilin, bound to ADP-Mg-actin and a sulfate ion
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Actin, ...
著者Teixeira-Nunes, M, Renault, L, Retailleau, P.
登録日2022-11-04
公開日2023-09-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin.
Plos Pathog., 19, 2023
5KLE
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BU of 5kle by Molmil
Structure of CBM_E1, a novel carbohydrate-binding module found by sugar cane soil metagenome, complexed with cellopentaose
分子名称: Carbohydrate binding module E1, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose
著者Liberato, M.V, Campos, B.M, Zeri, A.C.M, Squina, F.M.
登録日2016-06-24
公開日2016-09-21
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献A Novel Carbohydrate-binding Module from Sugar Cane Soil Metagenome Featuring Unique Structural and Carbohydrate Affinity Properties.
J.Biol.Chem., 291, 2016
8BR1
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BU of 8br1 by Molmil
ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, bound to Latrunculin-B-ATP-Mg-actin, and 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE and 2 Mg ions
分子名称: 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
著者Teixeira-Nunes, M, Renault, L, Retailleau, P.
登録日2022-11-22
公開日2023-09-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.044 Å)
主引用文献Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin.
Plos Pathog., 19, 2023
5KLS
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BU of 5kls by Molmil
Structure of CavAb in complex with Br-dihydropyridine derivative UK-59811
分子名称: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein, ...
著者Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A.
登録日2016-06-25
公開日2016-08-31
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.299 Å)
主引用文献Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016
6WXD
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BU of 6wxd by Molmil
SARS-CoV-2 Nsp9 RNA-replicase
分子名称: Non-structural protein 9, SULFATE ION
著者Littler, D.R, Gully, B.S, Riboldi-Tunnicliffe, A, Rossjohn, J.
登録日2020-05-10
公開日2020-05-20
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.
Iscience, 23, 2020
5LU3
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BU of 5lu3 by Molmil
The Structure of Spirochaeta thermophila CBM64
分子名称: 3,6,9,12,15-pentaoxaoctadecan-17-amine, 4-oxobutanoic acid, CALCIUM ION, ...
著者Correia, M.A.S, Romao, M.J, Carvalho, A.L.
登録日2016-09-07
公開日2017-02-15
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Stability and Ligand Promiscuity of Type A Carbohydrate-binding Modules Are Illustrated by the Structure of Spirochaeta thermophila StCBM64C.
J. Biol. Chem., 292, 2017
7C3F
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BU of 7c3f by Molmil
Crystal structure of ferredoxin: thioredoxin reductase and thioredoxin m2 complex
分子名称: Ferredoxin-thioredoxin reductase catalytic chain, chloroplastic, Ferredoxin-thioredoxin reductase variable chain, ...
著者Kurisu, G, Juniar, L, Tanaka, H.
登録日2020-05-12
公開日2020-10-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.3986 Å)
主引用文献Structural basis for thioredoxin isoform-based fine-tuning of ferredoxin-thioredoxin reductase activity.
Protein Sci., 29, 2020
5KMH
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BU of 5kmh by Molmil
Structure of CavAb in complex with Br-verapamil
分子名称: (2~{R})-2-(2-bromophenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-propan-2-yl-pentanenitrile, 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, ...
著者Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A.
登録日2016-06-27
公開日2016-08-31
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016
6C3P
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BU of 6c3p by Molmil
Cryo-EM structure of human KATP bound to ATP and ADP in propeller form
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
著者Lee, K.P.K, Chen, J, MacKinnon, R.
登録日2018-01-10
公開日2018-01-24
実験手法ELECTRON MICROSCOPY (5.6 Å)
主引用文献Molecular structure of human KATP in complex with ATP and ADP.
Elife, 6, 2017
8BJJ
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BU of 8bjj by Molmil
ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, bound to ATP-Mg-actin, human profilin 1 and a sulfate ion
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
著者Teixeira-Nunes, M, Renault, L, Retailleau, P.
登録日2022-11-04
公開日2023-09-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.699 Å)
主引用文献Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin.
Plos Pathog., 19, 2023
6WVG
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BU of 6wvg by Molmil
human CD53
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Green fluorescent protein, ...
著者Yang, Y, Liu, S, Li, W.
登録日2020-05-06
公開日2020-09-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Open conformation of tetraspanins shapes interaction partner networks on cell membranes.
Embo J., 39, 2020
8BR0
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BU of 8br0 by Molmil
ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin (residue Q3455 to L3863) in complex with 3'deoxyCTP and two manganese cations bound to Latrunculin-B-ADP-Mn-actin
分子名称: 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, Actin, ...
著者Texeira-Nuns, M, Retailleau, P, Renault, L.
登録日2022-11-22
公開日2023-09-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.218 Å)
主引用文献Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin.
Plos Pathog., 19, 2023
8BCH
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BU of 8bch by Molmil
Human Brr2 Helicase Region in complex with Sulfaguanidine
分子名称: 1-(4-aminophenyl)sulfonylguanidine, U5 small nuclear ribonucleoprotein 200 kDa helicase
著者Vester, K, Loll, B, Wahl, M.C.
登録日2022-10-15
公開日2023-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2.
Acta Crystallogr D Struct Biol, 79, 2023
5KLH
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BU of 5klh by Molmil
Crystal Structure of Trypanosoma brucei Procyclic Specific Surface Antigen-2
分子名称: SULFATE ION, Surface glycoprotein
著者Ramaswamy, R, Parker, M.L, Boulanger, M.J.
登録日2016-06-24
公開日2017-07-05
最終更新日2020-01-08
実験手法X-RAY DIFFRACTION (1.646 Å)
主引用文献Structural characterization reveals a novel bilobed architecture for the ectodomains of insect stage expressed Trypanosoma brucei PSSA-2 and Trypanosoma congolense ISA.
Protein Sci., 25, 2016
7CBP
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BU of 7cbp by Molmil
CryoEM structure of Zika virus with Fab at 4.1 Angstrom
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein E, Fab Heavy chain, ...
著者Tyagi, A, Ahmed, T, Shi, J, Bhushan, S.
登録日2020-06-13
公開日2020-07-08
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献A complex between the Zika virion and the Fab of a broadly cross-reactive neutralizing monoclonal antibody revealed by cryo-EM and single particle analysis at 4.1 angstrom resolution.
J Struct Biol X, 4, 2020
8BC9
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BU of 8bc9 by Molmil
Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 24
分子名称: 1,2-ETHANEDIOL, N-hydroxybenzenesulfonamide, Pre-mRNA-processing-splicing factor 8, ...
著者Vester, K, Loll, B, Wahl, M.C.
登録日2022-10-15
公開日2023-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2.
Acta Crystallogr D Struct Biol, 79, 2023
6C85
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BU of 6c85 by Molmil
Crystal structure of aspartate semialdehyde dehydrogenase from Blastomyces dermatitidis with p-benzoquinone
分子名称: 1,4-benzoquinone, Aspartate-semialdehyde dehydrogenase
著者Dahal, G.P, Viola, R.E.
登録日2018-01-24
公開日2019-01-30
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural insights into inhibitor binding to a fungal ortholog of aspartate semialdehyde dehydrogenase.
Biochem.Biophys.Res.Commun., 503, 2018
6C8F
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Crystal structure of Transient Receptor Potential (TRP) channel TRPV4 in the presence of cesium
分子名称: CESIUM ION, Transient receptor potential cation channel, subfamily V, ...
著者Deng, Z, Paknejad, N, Maksaev, G, Sala-Rabanal, M, Nichols, C.G, Hite, R.K, Yuan, P.
登録日2018-01-24
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (6.5 Å)
主引用文献Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms.
Nat. Struct. Mol. Biol., 25, 2018

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