8T2D

Ubiquitin variant i53:Mutant T12Y.T14E.L67R with 53BP1 Tudor domain

Summary for 8T2D

• Entry DOI: 10.2210/pdb8t2d/pdb
• Related: 8SVG 8SVH 8SVI 8SVJ
• Descriptor: Ubiquitin variant i53, Tumor protein p53 binding protein 1 (3 entities in total)
• Functional Keywords: inhibitor, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 22710.78

Authors

Partridge, J.R.,Holden, J.K.,Wibowo, A.S.,Mulichak, A. (deposition date: 2023-06-05, release date: 2024-03-27, Last modification date: 2024-04-03)

• Primary citation: Perez-Bermejo, J.A.,Efagene, O.,Matern, W.M.,Holden, J.K.,Kabir, S.,Chew, G.M.,Andreoletti, G.,Catton, E.,Ennis, C.L.,Garcia, A.,Gerstenberg, T.L.,Hill, K.A.,Jain, A.,Krassovsky, K.,Lalisan, C.D.,Lord, D.,Quejarro, B.J.,Sales-Lee, J.,Shah, M.,Silva, B.J.,Skowronski, J.,Strukov, Y.G.,Thomas, J.,Veraz, M.,Vijay, T.,Wallace, K.A.,Yuan, Y.,Grogan, J.L.,Wienert, B.,Lahiri, P.,Treusch, S.,Dever, D.P.,Soros, V.B.,Partridge, J.R.,Seim, K.L.; Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair.; Nat Commun, 15:2625-2625, 2024; PubMed: 38521763; DOI: 10.1038/s41467-024-46816-5

Experimental method

X-RAY DIFFRACTION (1.751 Å)