8BR0

ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin (residue Q3455 to L3863) in complex with 3'deoxyCTP and two manganese cations bound to Latrunculin-B-ADP-Mn-actin

Summary for 8BR0

Entry DOI	10.2210/pdb8br0/pdb
Related	8BJH 8BJI 8BJJ 8BO1
Descriptor	Actin, alpha skeletal muscle, intermediate form, Putative Adenylate cyclase,Profilin-1, LATRUNCULIN B, ... (7 entities in total)
Functional Keywords	bacterial nucleotidyl cyclase toxin, activated complex, toxin
Biological source	Vibrio nigripulchritudo SFn135 More
Total number of polymer chains	4
Total formula weight	217100.31
Authors	Texeira-Nuns, M.,Retailleau, P.,Renault, L. (deposition date: 2022-11-22, release date: 2023-09-20, Last modification date: 2023-10-04)
Primary citation	Teixeira-Nunes, M.,Retailleau, P.,Raoux-Barbot, D.,Comisso, M.,Missinou, A.A.,Velours, C.,Plancqueel, S.,Ladant, D.,Mechold, U.,Renault, L. Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19:e1011654-e1011654, 2023 Cited by PubMed: 37747912 DOI: 10.1371/journal.ppat.1011654 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.218 Å)

Structure validation