8BR0

ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin (residue Q3455 to L3863) in complex with 3'deoxyCTP and two manganese cations bound to Latrunculin-B-ADP-Mn-actin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Actin, alpha skeletal muscle, intermediate form	polymer	375	41862.6	2	UniProt (P68135) Pfam (PF00022) In PDB	Oryctolagus cuniculus (rabbit)
2	B, D	Putative Adenylate cyclase,Profilin-1	polymer	591	65232.9	2	UniProt (A0A6N3LUE9) UniProt (P07737) Pfam (PF03497) Pfam (PF00235) UniProt (by SIFTS) (A0A9P1NJI6) In PDB	Vibrio nigripulchritudo SFn135	Epididymis tissue protein Li 184a,Profilin I
3	A, C	LATRUNCULIN B	non-polymer		395.5	2	Chemie (LAB)
4	A, C	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)
5	A, B, C, D	MANGANESE (II) ION	non-polymer		54.9	6	Chemie (MN)
6	B, D	3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE	non-polymer		467.2	2	Chemie (CH1)
7		water	water		18.0	541	Chemie (HOH)

Sequence modifications

B, D: 455 - 896 (UniProt: A0A6N3LUE9)

PDB	External Database	Details
Gly 451	-	expression tag
Pro 452	-	expression tag
Gly 453	-	expression tag
Ser 454	-	expression tag
Pro 897	-	linker
Pro 898	-	linker
Pro 899	-	linker
Pro 900	-	linker
Gly 901	-	linker
Gly 902	-	linker

B, D: 903 - 1041 (UniProt: P07737)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	214190.9
Non-Polymers*	Number of molecules	12
	Total formula weight	2909.4
All*	Total formula weight	217100.3

*Water molecules are not included.