PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

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6ECL	Crystal Structure of a 1,2,4-Triazole Allosteric RNase H Inhibitor in Complex with HIV Reverse Transcriptase 分子名称: 1-[4-methoxy-3-[[5-methyl-4-(phenylmethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]ethanone, MANGANESE (II) ION, Reverse transcriptase/ribonuclease H 著者 Kirby, K.A, Sarafianos, S.G. 登録日 2018-08-08 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.385 Å) 主引用文献 Crystal Structure of a 1,2,4-Triazole Allosteric RNase H Inhibitor in Complex with HIV Reverse Transcriptase To be published
6DCY	The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 5-hydroxy-2-methyl-4-oxo-4H-pyran-3-carboxylic acid 分子名称: 5-hydroxy-2-methyl-4-oxo-4H-pyran-3-carboxylic acid, MANGANESE (II) ION, Polymerase acidic protein 著者 Dick, B.L, Morrison, C.N, Cohen, S.M. 登録日 2018-05-08 公開日 2018-11-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. J. Med. Chem., 61, 2018
2J8P	NMR structure of C-terminal domain of human CstF-64 分子名称: CLEAVAGE STIMULATION FACTOR 64 KDA SUBUNIT 著者 Qu, X, Perez-Canadillas, J.M, Agrawal, S, De Baecke, J, Cheng, H, Varani, G, Moore, C. 登録日 2006-10-27 公開日 2006-11-06 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 The C-Terminal Domains of Vertebrate Cstf-64 and its Yeast Orthologue RNA15 Form a New Structure Critical for Mrna 3'-End Processing. J.Biol.Chem., 282, 2007
6E0Q	The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid 分子名称: 1,2-ETHANEDIOL, 4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid, MANGANESE (II) ION, ... 著者 Dick, B.L, Morrison, C.N, Cohen, S.M. 登録日 2018-07-06 公開日 2018-11-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. J. Med. Chem., 61, 2018
6DZQ	The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic acid 分子名称: 1,2-ETHANEDIOL, 3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic acid, MANGANESE (II) ION, ... 著者 Dick, B.L, Morrison, C.N, Cohen, S.M. 登録日 2018-07-05 公開日 2018-11-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. J. Med. Chem., 61, 2018
3H7H	Crystal structure of the human transcription elongation factor DSIF, hSpt4/hSpt5 (176-273) 分子名称: BETA-MERCAPTOETHANOL, Transcription elongation factor SPT4, Transcription elongation factor SPT5, ... 著者 Wenzel, S, Wohrl, B.M, Rosch, P, Martins, B.M. 登録日 2009-04-27 公開日 2009-12-08 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface Biochem.J., 425, 2010
4EJS	Structure of yeast elongator subcomplex Elp456 分子名称: Elongator complex protein 4, Elongator complex protein 5, Elongator complex protein 6 著者 Lin, Z, Zhao, W, Long, J, Shen, Y. 登録日 2012-04-07 公開日 2012-05-02 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.606 Å) 主引用文献 Crystal structure of elongator subcomplex Elp4-6 J.Biol.Chem., 287, 2012
5HBM	Crystal Structure of a Dihydroxycoumarin RNase H Active-Site Inhibitor in Complex with HIV-1 Reverse Transcriptase 分子名称: (7,8-dihydroxy-2-oxo-2H-chromen-4-yl)acetic acid, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, MANGANESE (II) ION, ... 著者 Kirby, K.A, Sarafianos, S.G. 登録日 2015-12-31 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.043 Å) 主引用文献 Crystal Structure of a Dihydroxycoumarin RNase H Active-Site Inhibitor in Complex with HIV-1 Reverse Transcriptase To Be Published
4NST	Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, ... 著者 Boesken, C.A, Farnung, L, Anand, K, Geyer, M. 登録日 2013-11-29 公開日 2014-03-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The structure and substrate specificity of human Cdk12/Cyclin K. Nat Commun, 5, 2014
6ONJ	Crystal structure of PPARgamma ligand binding domain in complex with TRAP220 peptide and agonist rosiglitazone 分子名称: 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), Mediator of RNA polymerase II transcription subunit 1, ... 著者 Shang, J, Kojetin, D.J. 登録日 2019-04-22 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A molecular switch regulating transcriptional repression and activation of PPAR gamma. Nat Commun, 11, 2020
6ER0	6th KOW domain of human hSpt5 分子名称: Transcription elongation factor SPT5 著者 Hahn, L, Schweimer, K, Roesch, P, Woehrl, B.M. 登録日 2017-10-16 公開日 2018-10-31 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structure and nucleic acid binding properties of KOW domains 4 and 6-7 of human transcription elongation factor DSIF. Sci Rep, 8, 2018
6EIH	The crystal structure of 14-3-3 epsilon in complex with the phosphorylated NELFE peptide 分子名称: 14-3-3 protein epsilon, SER-ILE-SEP-ARG 著者 Akutsu, M, Wagner, S.A, Beli, P. 登録日 2017-09-19 公開日 2018-02-14 最終更新日 2019-10-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun, 9, 2018
6EQY	4th KOW domain of human hSpt5 分子名称: Transcription elongation factor SPT5 著者 Zuber, P.K, Schweimer, K, Roesch, P, Woehrl, B.M. 登録日 2017-10-16 公開日 2018-10-17 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structure and nucleic acid binding properties of KOW domains 4 and 6-7 of human transcription elongation factor DSIF. Sci Rep, 8, 2018
3BLQ	Crystal Structure of Human CDK9/cyclinT1 in Complex with ATP 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Cell division protein kinase 9, ... 著者 Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. 登録日 2007-12-11 公開日 2008-07-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
8J8Q	Structure of the four-component Paf1 complex from Saccharomyces eubayanus 分子名称: CDC73-like protein, CTR9-like protein, PAF1-like protein, ... 著者 Wang, Z, Qin, Y, Zhou, Y, Cao, Y. 登録日 2023-05-02 公開日 2023-05-24 最終更新日 2023-06-14 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Structural Basis of the Transcriptional Elongation Factor Paf1 Core Complex from Saccharomyces eubayanus . Int J Mol Sci, 24, 2023
8J8P	Structure of the four-component Paf1 complex from Saccharomyces eubayanus 分子名称: CDC73-like protein, CTR9-like protein, PAF1-like protein, ... 著者 Wang, Z, Qin, Y, Zhou, Y, Cao, Y. 登録日 2023-05-02 公開日 2023-05-24 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Basis of the Transcriptional Elongation Factor Paf1 Core Complex from Saccharomyces eubayanus . Int J Mol Sci, 24, 2023
3TDB	Human Pin1 bound to trans peptidomimetic inhibitor 分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, N-[(1E,2R)-1-[(2R)-2-{[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl}cyclopentylidene]-3-(phosphonooxy)propan-2-yl]-L-phenylalaninamide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 著者 Zhang, M, Zhang, Y. 登録日 2011-08-10 公開日 2012-06-27 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.267 Å) 主引用文献 Structural and Kinetic Analysis of Prolyl-isomerization/Phosphorylation Cross-Talk in the CTD Code. Acs Chem.Biol., 7, 2012
6R4T	Crystal structure of the Pri1 subunit of human primase bound to vidarabine triphosphate 分子名称: 1,2-ETHANEDIOL, 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-amine, DNA primase small subunit, ... 著者 Kilkenny, M.L, Pellegrini, L. 登録日 2019-03-24 公開日 2019-09-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine. Acs Chem.Biol., 14, 2019
6R5E	Crystal structure of the Pri1 subunit of human primase bound to 2F-ATP 分子名称: 1,2-ETHANEDIOL, 2-fluoro-ATP, DNA primase small subunit, ... 著者 Kilkenny, M.L, Pellegrini, L. 登録日 2019-03-24 公開日 2019-09-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine. Acs Chem.Biol., 14, 2019
6R4S	Crystal structure of the Pri1 subunit of human primase bound to ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA primase small subunit, MANGANESE (II) ION, ... 著者 Kilkenny, M.L, Pellegrini, L. 登録日 2019-03-24 公開日 2019-09-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine. Acs Chem.Biol., 14, 2019
6R5D	Crystal structure of the Pri1 subunit of human primase bound to dATP 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA primase small subunit, ... 著者 Kilkenny, M.L, Pellegrini, L. 登録日 2019-03-24 公開日 2019-09-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine. Acs Chem.Biol., 14, 2019
6R4U	Crystal structure of the Pri1 subunit of human primase bound to fludarabine triphosphate 分子名称: 1,2-ETHANEDIOL, 2-fluoro-9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-a mine, DNA primase small subunit, ... 著者 Kilkenny, M.L, Pellegrini, L. 登録日 2019-03-24 公開日 2019-09-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine. Acs Chem.Biol., 14, 2019
5JW9	The Crystal Structure of ELL2 Oclludin Domain and AFF4 peptide 分子名称: AF4/FMR2 family member 4, RNA polymerase II elongation factor ELL2 著者 Qi, S, Hurley, J.H. 登録日 2016-05-11 公開日 2017-02-08 実験手法 X-RAY DIFFRACTION (2.003 Å) 主引用文献 Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription. Nat Commun, 8, 2017
3TCZ	Human Pin1 bound to cis peptidomimetic inhibitor 分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, N~2~-({(1R,2Z)-2-[(2R)-2-(formylamino)-3-(phosphonooxy)propylidene]cyclopentyl}carbonyl)-L-argininamide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 著者 Zhang, M, Zhang, Y. 登録日 2011-08-09 公開日 2012-06-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and Kinetic Analysis of Prolyl-isomerization/Phosphorylation Cross-Talk in the CTD Code. Acs Chem.Biol., 7, 2012
3NNW	Crystal structure of P38 alpha in complex with DP802 分子名称: 2-[3-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]imino}-2,5-dihydro-1H-pyrazol-1-yl)phenyl]acetamide, Mitogen-activated protein kinase 14 著者 Abendroth, J. 登録日 2010-06-24 公開日 2010-09-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region Bioorg.Med.Chem.Lett., 20, 2010

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